Sarcoma and Solid Tumors
Solid tumors are masses that can grow almost anywhere in the body with the exception of the blood (hematological cancer). Solid tumors as split into two categories: sarcomas and carcinomas.
Sarcoma and Solid Tumor Clinical Studies
Our research team looks for ways to decrease the size and impact of solid tumors, or to slow the growth of the tumor in the safest way possible. This is determined through a combination of inhibitors, radiation treatments, and other therapies. Our researchers also evaluate tumors through biopsies to better understand what the genetic make-up of the tumor is and how it can be treated.
Open Sarcoma and Solid Tumor Clinical Studies
Cell Therapy
Researchers Studying Donor NK Cell Infusions Combined With IV Medications in Patients With Relapsed or Refractory Pediatric Sarcomas
Help researchers determine if adding infusions of a type of immune cell called a “natural killer,” or NK cell to the sarcoma chemotherapy regimen GEM/DOX (gemcitabine and docetaxel) is safe and can improve outcomes in people with childhood sarcomas that have relapsed or not responded to prior therapies.
Sarcoma
Blood Biomarkers for Detecting Minimal Residual Disease in Pediatric Sarcomas
The purpose of this study is to see if detecting cell-free plasma tumor DNA (ptDNA) and circulating tumor cells (CTC) can predict recurrence of disease in patients who are in radiographic remission 2-3 weeks after treatment.
Solid Tumors
Study of ctDNA to Predict Outcomes in New Cases of Ewing Sarcoma or Osteosarcoma
The purpose of this study is to evaluate whether circulating tumor deoxyribonucleic acid (ctDNA) in the blood can provide information about the chances of Ewing sarcoma or osteosarcoma coming back after treatment and locate specific genetic alterations.
A Phase 2 Study of Oral Medication Cabozantinib to Help Maintain Treatment in Children With High-Risk Solid Tumors
This study will look at how cabozantinib works on more types of pediatric cancers, including neuroblastomas, which are very serious and have few treatment options.
Additional Studies Related to Sarcoma and Solid Tumors
Testicular Tissue Cryopreservation for Fertility Preservation
This clinical trial will have separate portions of the harvested testicular tissues and/or derivative cells designated for research and for cryopreservation for a resource for future elective procedures to attempt fertility restoration.
How Vincristine Works in Babies
This pilot trial compares drug exposure levels using a new method for dosing vincristine in infants and young children compared to the standard dosing method based on body surface area (BSA) in older children.
Study of Tiragolumab and Atezolizumab in Patients With SMARCB1- or SMARCA4-Deficient Tumors
This trial studies how well tiragolumab and atezolizumab works when given to children and adults with SMARCB1 or SMARCA4 deficient tumors that have either come back (relapsed) or do not respond to therapy (refractory).
Study of Lurbinectedin in Pediatric and Young Adult Patients With Relapsed/Refractory Ewing Sarcoma
The purpose of this study is to evaluate the safety, tolerability, pharmacokinetics (PK), recommended phase 2 dose (RP2D), and effectiveness of lurbinectedin monotherapy in pediatric participants with previously treated solid tumors.
Evolutionary Therapy for Rhabdomyosarcoma
This clinical trial will evaluate four different strategies of chemotherapy schedules in newly diagnosed participants with metastatic fusion positive (alveolar) rhabdomyosarcoma.
Study of Very Low-Risk and Low-Risk Fusion Negative Rhabdomyosarcoma
This phase III trial aims to maintain excellent outcomes in patients with very low risk rhabdomyosarcoma (VLR-RMS) while decreasing the burden of therapy using treatment with 24 weeks of vincristine and dactinomycin (VA) and examines the use of centralized molecular risk stratification in the treatment of rhabdomyosarcoma.
Trial Comparing Open vs Thoracoscopic Procedure for Lung Metastases in Osteosarcoma
The purpose of this study is to determine if open surgical resection is superior to thoracoscopic resection for thoracic event-free survival (tEFS) in patients with resectable oligometastatic pulmonary osteosarcoma.
Umbrella Long-Term Follow-Up Protocol
This clinical trial keeps track of and collects follow-up information from patients who are currently enrolled on or have participated in a Children's Oncology Group study.
Key Adverse Events after Childhood Cancer
This clinical trial studies cancer survivors to identify those who are at increased risk of developing late-occurring complications after undergoing treatment for childhood cancer.
