Kidney Disease Clinical Research
Physician-Scientists in Nationwide Children’s Pediatric Nephrology Division are dedicated to identifying new biomarkers and therapeutic targets that may impact the lives of children with kidney and urinary tract diseases. Our team participates in clinical, translational, and basic science research that is funded by industry, professional societies, the National Institutes of Health, and the Abigail Wexner Research Institute. Our team has over forty ongoing IRB-approved research studies.
Kidney Disease Clinical Studies
Studies Now Enrolling Participants
Chronic Kidney Disease in Children Prospective Cohort Study (CKiD)
The goals of this observational study are to identify risk factors that contribute to a decline in kidney function and to define how progressive decline in kidney function impacts the child’s health.
Cure Glomerulonephropathy Network (CureGN)
The goal of this study is to identify markers of glomerular disease, including minimal change disease, focal segmental glomerulosclerosis, membranous nephropathy, and immunoglobulin A nephropathy.
X-linked Hypophosphatemia Disease Monitoring Program
This program is a global prospective, multicenter, longitudinal, long-term outcomes program for subjects on or off any treatment designed to characterize XLH disease presentation and progression, assess long-term safety and effectiveness of burosumab (Ultragenyx), as well as prospectively investigate longitudinal change over time across biomarker(s), clinical assessments, and patient/caregiver-reported outcome measures in a representative population.
The Contribution of Ribonuclease 7 to Urinary Tract Antibacterial Defense
The goal of this study is to identify new ways to develop Ribonuclease 7 to treat and prevent infections in the urinary tract.
Linking Insulin Signaling to Antimicrobial Peptide Production and the Kidney’s Antibacterial Defenses
The goal of this study is to investigate if children with Type 1 or Type 2 diabetes mellitus have abnormal immune profiles that increase their infection risk.
We're Externally Supported
Our physician scientists are also externally supported in preclinical studies that investigate:
- Mechanisms that prevent obstructive kidney injury, one of the leading causes of pediatric chronic kidney disease. This work is led by Dr. Brian Becknell and supported by the American Society of Nephrology.
- New therapies are needed to prevent urinary tract infections, one of the most common and serious bacterial infections in clinical practice. National Institutes of Health supported projects led by Dr. Brian Becknell and John David Spencer are investigating mechanisms that can be developed to prevent infection.
Other Areas Our Team Investigates
- Adolescent transplant patients’ adherence to their medication and lifestyle regimen, and transitioning them from pediatric- to adult-centered care.
- The diagnosis and impact of hypertension in children and children with kidney transplantation.
- The impact of glomerular disease on child health.
- New medications that prevent kidney transplant rejection.
- The impact of renal tubular diseases, including cystinosis and nephrogenic diabetes insipidus, on child health and development.
- Mechanisms in which children in peritoneal dialysis develop infections.
- Urinary tract development and its impact renal function.
