Immunology Clinical Research

What is the purpose of this study?

Looking for healthy adults from 19-75 years old to develop normal values for interpretation of immunological tests in adults with disorders of the immune system (primary or secondary immunodeficiencies)

Who can participate in this study?

An adult who: 

• Is age 19 or older 

• Is healthy with no significant medical diagnoses, particularly immune-related diagnoses (check with us to see if unsure) 

• Has no other chronic medical conditions that can affect results of immunological studies (check with us to see if unsure) 

• Is not on any medication known to alter immune status or function (check with us to see if unsure) 

• Has not undergone recent surgery, chemotherapy, radiation or transplantation 

• Has had no infections within the last 2 months 

What will happen during this study?

Voluntary participation involves blood draw at Nationwide Children’s Hospital. If you qualify you would be eligible to provide a sample once every 2 months (not more than 6 times a year). Your participation in this study would be of indefinite duration unless you voluntarily withdraw or have medical changes that would exclude you from this study. A total of 30-50 cc (1.5-3 tablespoons equivalent) blood will be collected each time. Collections will be performed at a scheduled time at the Nationwide Children’s Hospital Outpatient Care Center (555 South 18th St. Columbus, OH 43205). Parking is available and will be validated. You will be compensated for your time, for each blood draw. 

Who can I contact for more information?

Please contact Amy Kayatin at (614) 722-2994 or Joann Petty at (614) 722-5422.

What is the purpose of this study?

We’re looking for healthy children from newborns to 18 years old to help us understand immune disorders. We’ll compare healthy children and teens to children and teens with immunodeficiencies. 

Who can participate in this study?

A child who: 

• Is a newborn to 18 years of age 
• Is healthy with no significant medical diagnoses, particularly immune-related diagnoses (check with us to see if unsure) 
• Has no other chronic medical conditions that can affect results of immunological studies (check with us to see if unsure) 
• Is not on any medication known to alter immune status or function (check with us to see if unsure) 
• Has not undergone recent surgery, chemotherapy, radiation or transplantation 
• Has had no infections within the last 2 months 

What will happen during this study?

Volunteers will visit Nationwide Children’s Hospital for a blood draw once every three months. Your child’s participation in this study would be for an indefinite period of time unless you voluntarily withdraw or have medical changes that would exclude your child from this study. Visits will be at the Nationwide Children’s Hospital Outpatient Care Center at 555 South 18th Street, Columbus, OH 43205. Parking is available and will be validated. Your child will be compensated for each blood draw. 

Who can I contact for more information?

Please contact Amy Kayatin at (614) 722-2994 or Joann Petty at (614) 722-5422. 

ACV01 Clinical Trial Investigating Vaccine Booster Response in Autoimmune Disease Patients

Many people with autoimmune disease are at risk for COVID-19 infection because of the medications they take. These individuals are now eligible to receive an additional dose of an mRNA COVID-19 vaccine.

However, there are large gaps in our understanding of who will benefit from an additional dose of vaccine and how to make it work better.

The Autoimmunity Centers of Excellence, sponsored by the National Institute of Allergy and Infectious Diseases, has opened a clinical trial called ACV01 to address many of these questions.

As new information is learned, the ACV01 study will change to answer questions about more autoimmune diseases, other medications, and pediatric populations.

Help us learn as much as we can about the best way to help people with autoimmune patients protect themselves against COVID-19.

Trial Specifics

• DISEASE INVOLVEMENT: The trial is enrolling people with lupus, rheumatoid arthritis, scleroderma, multiple sclerosis, and pemphigus.
• VACCINE RESPONSE: Participants must have had a low antibody response to their initial vaccine regimen to participate.
• REQUIRED MEDICATIONS: Participants must be taking mycophenolate, methotrexate, or a B-cell depleting therapy like rituximab or ofatumumab.
• HELP US CLOSE THE GAPS: To find out more visit our ACV01 public website.

Visit AutoimmuneCovidBooster.org to learn more.

Join this clinical study to research an investigational medicine to prevent lung infections caused by respiratory syncytial virus.

MELODY is a clinical research study looking at an investigational medication to see how safe it is and whether it works to prevent respiratory syncytial virus (RSV) disease in healthy babies. Babies may be eligible for the study if they:

• Were born at 35 weeks or later
• Have no known history of RSV infection or lung diseases

The study will include about 3000 babies globally. If you decide to take part, your baby will be in the MELODY Study for about 1 year and 6 months and will have at least 7 visits to the study center. Your baby will be monitored throughout the study for respiratory illnesses.

Want to Know More?

If you are interested in learning more about the MELODY Study, please contact MELODY@NationwideChildrens.org.

What’s the purpose of the study?

The purpose of the study is to help researchers collect data from healthy adults to compare with adults being tested for problems with their immune system.

Who can take part in the study?

You are eligible to participate if you:

• Are a young adult (19 to 30 years old).
• Are healthy with no significant medical (particularly immune-related) diagnoses.
• Have no chronic (long lasting) conditions that can affect results of immune-related studies.
• Are not on any medication known to alter immune status or function.
• Are not a smoker.
• Are not someone who has undergone recent surgery, chemotherapy, radiation or transplantation.
• Have a Body Mass Index (BMI) in the healthy range.
• Have not had any infections within the last two months.

What will happen during the study?

• If you qualify, you would be eligible to have blood drawn at Nationwide Children’s Hospital once every two months (not more than six times a year).
• A total of 30-50 cc (about 1.5 to 3 tablespoons) of blood will be collected each time.
• Blood draws will be scheduled at times that are convenient to you at the Nationwide Children’s Outpatient Care Center.

Participation will last until you choose to withdraw or have medical changes that would exclude you from the study.

Will I be compensated for my time?

You will be compensated for your time for each blood draw, and parking is available and will be validated.

For more information or to sign up, email Tyler.Rogerson@NationwideChildrens.org or call (614) 722-5422.

Principal Investigator: Dr. Roshini Abraham