The Contribution of Ribonuclease 7 to Urinary Tract Antibacterial Defense
Phase: Recruiting
Condition(s): Urinary tract infections (UTI)
What Is the Purpose of This Study?
Urinary tract infections (UTI) are among the most common and serious infections encountered in clinical practice and no proven treatment options exist to prevent UTI. Research now suggests that cells in the kidney and bladder produce an antibacterial peptide called Ribonuclease 7 that is important for fighting infection. This National Institutes of Health supported R01 application will identify new ways to develop Ribonuclease 7 to treat and prevent infections in the urinary tract. Also, it will investigate if children with UTI or recurrent UTI have abnormal Ribonuclease 7 production.
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Urinary Tract Infection (UTIs)
Urinary Tract Infections (UTIs) are typically caused by a bacterial infection in the urethra and bladder. Left untreated, a UTI can spread beyond the bladder and travel into the ureters and kidneys, where it becomes an acute kidney infection (pyelonephritis).
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