Linking Insulin Signaling to Antimicrobial Peptide Production and the Kidney’s Antibacterial Defenses
Phase: Recruiting
Condition(s): Urinary tract infections (UTI), Kidney Infections
What Is the Purpose of This Study?
Urinary tract and kidney infections are serious infections that can cause many health complications and death in people with diabetes. Research now suggests that specialized cells in the kidney are important to fighting urinary tract infections. By studying how insulin regulates the antibacterial mechanisms in these cells, we can gain insight into why people with diabetes develop infections and develop new options to treat and prevent them. This National Institutes of Health supported R01 application will investigate if children with Type 1 or Type 2 diabetes mellitus have abnormal immune profiles that increase their infection risk.
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Urinary Tract Infection (UTIs)
Urinary Tract Infections (UTIs) are typically caused by a bacterial infection in the urethra and bladder. Left untreated, a UTI can spread beyond the bladder and travel into the ureters and kidneys, where it becomes an acute kidney infection (pyelonephritis).
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