Hematologic Disorders
Hematologic disorders are conditions found in the blood and blood forming organs. This includes blood cell cancers, genetic disorders, anemia, HIV related conditions, sickle cell disease, and complications do to chemotherapy treatment or transfusions.
Our hematology team leads clinical trials that evaluate effective treatments through medicines, compare new therapies against existing protocols, and study groups of patients with hematologic conditions to decrease pain and reduce patient’s dependency on current treatments.
Protocol ID: SCTaware
Disease: Sickle Cell Trait
Who can participate?: Biological parents of young children (<3 years old) with SCT identified by NBS who are referred and present for in-person SCT education at NCH
Protocol ID: ATHN9
Disease: VWD
Who can participate?: Participants with severe Von Willebrand Disease with Type 3 VWD or VWF:RCo, VWF:GPlbM or VWF:Ag ≤30% of pooled normal control plasma on more than one occasion; Participants with clinically severe VWD as defined by VWF:RCo, VWF:GPlbM or VWF:Ag ≤40% of normal with severe bleeding phenotype defined as requiring recurrent use of factor concentrates; and Co-enrollment in the ATHNdataset.
Lead Researcher: Amy L. DunnProtocol ID: ICON 3
Disease: Thrombocytopenia
Who can participate?: Age: 1- <18 years. Newly diagnosed ITP (<3 months from diagnosis (first abnormal platelet count). Platelets <30 x109/L at screening
Lead Researcher: Melissa J. Rose
Protocol ID: SHP677-304
Disease: Von Willebrand Disease (VWD)
Who Can Participate?: Ages 12 to 99
Lead Researcher: Amy L. Dunn, MD
Protocol ID: PIDTC 6901
Who can participate?: SCID being treated with transplant or PEG-ADA or gene therapy
Protocol ID: IV Iron
Disease: IBD
Who Can Participate?: Ages 8 to 21
Lead Researcher: Amanda E. Jacobson-Kelly, MD
Protocol ID: Mobile App
Disease: Heavy Menstrual Bleeding (HMB)
Who Can Participate?: Ages 10 to 14
Lead Researcher: Sarah H. O'Brien. MD
Protocol ID: ENGAGE
Disease: Sickle Cell
Who can participate?: Ages 0 to 5 (inclusive) with SCD diagnosis
Lead Researcher: Susan E. Creary
Protocol ID: ICON Bank
Disease: Thrombocytopenia
Who can participate?: Patients diagnosed with immune thrombocytopenia (including Evans syndrome if ITP is present).
Lead Researcher: Melissa J. Rose
Protocol ID: HMB & Low VWF H-39295
Disease: Menorrhagia
Who can participate?: Post-menarchal females < 21 years of age with HMB (defined as PBAC score >100)
Protocol ID: HOPS
Disease: Sickle Cell Anemia
Who can participate?: Children with confirmed (HbSS, HbSD or Hbβ0-thalassemia) who are initiating hydroxyurea therapy, following a discussion with their local clinical team, will be eligible for this study.
Lead Researcher: Susan E. Creary
Protocol ID: Copper Deficiency
Disease: J/GJ Tube Dependency
Who Can Participate?: Ages 6 months to 21 years
Lead Researcher: Amanda E. Jacobson-Kelly, MD
Protocol ID: ATHN10
Diseases: Rare Coagulation Disorders
Who Can Participate?: Ages 0 to 99
Lead Researcher: Amy L. Dunn, MD
Protocol ID: Baxalta 071102 rVWF (Von Vendi)
Disease: Von Willebrand Disease
Who can participate?: 3 age cohorts:
- Cohort 1: >12 to <18 years
- Cohort 2: >6 to <12 years (after 6 subjects from Cohort 1)
- Cohort 3: <6 years (after 6 subjects in Cohort 2)
- Severe VWD
Lead Researcher: Amy L. Dunn
Protocol ID: NGAM-10
Disease: Immune Thrombocytopenia (ITP)
Who Can Participate?: Ages 1 to 17
Lead Researcher: Melissa J. Rose, DO
Protocol ID: LCH REASON
Disease: Langerhans cell histiocytosis (LCH)
Who Can Participate?: Confirmed diagnosis of Langerhans cell histiocytosis, ages 0 to 21
Lead Researcher: Amanda E. Jacobson-Kelly, MD
Protocol ID: BMT CTN 1507
Disease: SCD
Who can participate?: Must be b/t 5 – 14 yrs and had a stroke. Must be b/t 15 – 45yrs and meet additional protocol criterion. Have a donor who is a half match.
Lead Researcher: Hemalatha Geetharani Rangarajan
Protocol ID: Medicaid Data in SCD
Disease: Sickle Cell Disease (SCD)
Lead Researcher: Sarah H. O'Brien. MD
Protocol ID: FRONTIER1
Disease: Hemophilia A
Who Can Participate?: Ages 12 to 64
Lead Researcher: Amy L. Dunn, MD
Protocol ID: ECLIPSE
Disease: Hemophilia B
Who Can Participate?: Ages 16 to 99
Lead Researcher: Amy L. Dunn, MD
Protocol ID: SECURE-SCD Registry
Disease: Sickle Cell Disease (SCD)
Who Can Participate?: Ages 0 to 99
Lead Researcher: Anthony D. Villella, MD
Protocol ID: HMB Registry
Disease: Menorrhagia
Who can participate?: Ages < 21, patients who are new referrals to a Young Women Hematology Clinic or General Hematology Clinic for evaluation of HMB
Protocol ID: SCN Registry
Disease: SCN
Who can participate?: Age greater than three months
Lead Researcher: Melissa J. Rose, DO