Other/Multiple Specialties

These trials involve finding solutions for patients who have more than one condition involving hematology, oncology, & bone and marrow transplant. Multispecialty studies focus on new ways to treat the whole patient through by studying the correlations between different diseases.

A Phase I/II Study of Pembrolizumab (MK-3475) in Children with advanced melanoma or a PD-L1 positive advanced, relapsed or refractory solid tumor or lymphoma

Protocol ID: ADVL1621

Disease: Solid Tumor, Lymphoma

Who can participate?: Be between 6 months and less than 18 years of age on day of signing informed consent/assent. (NBL and Osteo closed).

Lead Researcher: Mark A. Ranalli

An Intermediate-size, Expanded Access Protocol to Provide Brincidofovir for the Treatment of Serious Adenovirus Infection or Disease

Protocol ID: CMX001-351

Disease: Adenovirus

Who can participate?: Male or female, aged 2 months and older.

Lead Researcher: Hemalatha Geetharani Rangarajan

Analysis of Patients Treated for Wiskott-Aldrich Syndrome Since January 1, 1990

Protocol ID: PIDTC 6904

Disease: Wiskott-Aldrich Syndrome 

Lead Researcher: Rolla F. Abu-Arja

CHOP HAdV: Outcomes of Human Adenovirus (HAdV) Infection and Disease in Pediatric Allogeneic Stem Cell Transplant Recipients: A Prospective Multicenter Observational Cohort

Protocol ID: CHOP HAdV

Disease: Adenovirus 

Who can participate?: Age less than 18 years of age at the time of transplant.

Lead Researcher: Monica I. Ardura

Neuropsychological, Social, Emotional, and Behavioral Outcomes in Children with Cancer

Protocol ID: ALTE07C1

Disease: Multiple

Who can participate?: No specific age requirement.

Lead Researcher: Mark A. Ranalli

The Project: Every child Protocol: A Registry, Eligibility Screening, Biology and Outcome Study

Protocol ID: APEC14B1

Disease: All Cancer

Who can participate?: Subjects must be ≤ 25 years of age at time of original diagnosis, except for patients who are being screened specifically for eligibility onto a COG (or COG participating NCTN) therapeutic study, for whom there is a higher upper age limit.

Lead Researcher: Mark A. Ranalli, MD

Umbrella Long-Term Follow-Up Protocol

Protocol ID: ALTE05N1

Disease: Multiple

Who can participate?: No specific age requirement.

Lead Researcher: Mark A. Ranalli

A Phase I Trial of Dose Escalation of Metformin in Combination with Vincristine, Irinotecan, and Temozolomide in Children with Relapsed or Refractory Solid Tumors

Protocol ID: MCC16962/VIT in Solid Tumors (Sunshine)

Disease: Solid Tumor, CNS Malignancy

Who can participate?: Patients must be > 1 year of age and ≤ 18 years of age at time of initiation of protocol therapy.

Lead Researcher: Bhuvana A. Setty, MD

Personalized Medicine: Pediatric Total Cancer Care Protocol

Protocol ID: MCC17319/TCC Sunshine

Disease: Diagnosed or at Risk for Cancer

Who can participate?: <18 years of age at diagnosis

Lead Researcher: Bhuvana A. Setty, MD

Thrombin Generation in Nephrotic Syndrome

Protocol ID: Nephrotic Syndrome

Disease: Nephrotic Syndrome

Who can participate?:

Lead Researcher: Bryce A. Kerlin, MD

A Prospective Natural History Study of Diagnosis, Treatment and Outcomes of Children with SCID Disorders

Protocol ID: PIDTC 6901

Disease: SCID Disorders

Who can participate?: < 2 years of age

Lead Researcher: Rolla F. Abu-Arja, MD

Ovarian Tissue Freezing For Fertility Preservation In Girls Facing A Fertility Threatening Medical Diagnosis or Treatment Regimen: A Study by the National Physicians Cooperative of the Oncofertility Consortium at Nationwide Children's Hospital

Protocol ID: Ovarian Tissue Freezing for Fertility Preservation

Disease: All Cancer

Who can participate?: Be female, less than or equal to 30 years old who are post-menarche.

Lead Researcher: Nicholas D. Yeager, MD

Institute for Genomic Medicine Comprehensive Profiling for Cancer and Blood Disorders

Protocol ID: IGM Comprehensive Heme-Onc Profiling

Disease: All cancer

Who can participate?: Minor or adult patients are eligible

Lead Researcher: Catherine E. Cottrell, PhD