Researchers Studying Donor NK Cell Infusions Combined With IV Medications in Patients With Relapsed or Refractory Pediatric Sarcomas
Phase: Recruiting
First Posted: February
Condition(s): Osteosarcoma, Ewing Sarcoma, Rhabdomyosarcoma, Non-rhabdomyosarcoma Soft Tissue Sarcoma
NCT Number: NCT05634369 Other Study ID Number(s): TINKS, MCC21704
What Is the Purpose of This Study?
To determine if adding infusions of a type of immune cell called a “natural killer,” or NK cell to the sarcoma chemotherapy regimen GEM/DOX (gemcitabine and docetaxel) is safe and can improve outcomes in people with childhood sarcomas that have relapsed or not responded to prior therapies.
Who Can Take Part in This Study?
People who may be eligible for this study:
- Have had a relapsed or refractory osteosarcoma, Ewing sarcoma, rhabdomyosarcoma or non-rhabdomyosarcoma soft tissue sarcoma.
- Are 12-40 years old.
For a full list of eligibility requirements, visit https://clinicaltrials.gov/study/NCT05634369
What Will Happen During This Study?
- Participants will receive IV chemo therapy on Days 1 and 8 and NK cells on Day 12 of each cycle.
- Each cycle is 21 days long. Participants can receive up to 8 cycles.
Principal Investigator
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