TB19DHCT: Depletion of αβT Cells and CD19+ B Cells in Alternative Donor Stem Cell Transplant for Children and Young Adults with Blood Cancers
Phase: Recruiting
First Posted: October
Condition(s): Hematopoietic Stem Cell Transplantation (HSCT), Hematologic Malignancy
NCT Number: NCT06082947
What Is the Purpose of This Study?
To study the one-year overall survival of patients undergoing allogeneic hematopoietic stem cell transplantation (HSCT) using the T-Cell Receptor (TCR) αβ/CD19+ depleted platform and grafts from alternative donors (MUD, MMUD and haploidentical).
Who Can Take Part in This Study?
- Patients needing an allogeneic stem cell transplant for blood cancers without a matched sibling donor.
- Karnofsky (for >16 years) or Lansky (for ≤16 years) Performance Score of 60% or higher before transplant.
- Informed consent required from the patient or legal guardian if patient is 18 or older; for patients under 18, guardian consent and patient assent (if appropriate) are needed.
- Adequate organ function within 4 weeks before starting transplant preparation. Patients must meet organ function requirements for Myeloablative (MAC) or Reduced Intensity (RIC) conditioning.
- High-resolution HLA match available.
- Age 30 years or younger.
For a full list of eligibility requirements, visit https://clinicaltrials.gov/study/NCT06082947
What Will Happen During This Study?
- Patients will be hospitalized to receive their αβT cell/CD19+ B cell depleted infusion. They will continue to be hospitalized after the infusion until they meet the standards for discharge.
- After discharge, they will be followed at least until one year post infusion to see how you are doing.
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