A Phase 2 Study of Oral Medication Cabozantinib to Help Maintain Treatment in Children With High-Risk Solid Tumors
Phase: Recruiting
Condition(s): Solid Tumors, Neuroblastoma, Sarcoma
NCT Number: NCT05135975 Other Study ID Number(s): CaboMain
What Is the Purpose of This Study?
This study will look at how cabozantinib works on more types of pediatric cancers, including neuroblastomas, which are very serious and have few treatment options. The goal is to see if cabozantinib can prevent or slow down the return of these cancers and help control the disease for a longer time or even cure it.
Who Can Take Part in This Study?
People who may be eligible for this study are ages 18 months to 40 years with one of these conditions:
- Neuroblastoma
- Relapsed/refractory sarcomas and other solid tumors
- Metastatic sarcomas after frontline therapy
For a full list of eligibility requirements, visit https://clinicaltrials.gov/study/NCT05135975
What Will Happen During This Study?
- Enrolled patients will take cabozantinib maleate tablets 40 mg/m2/ per day, to to a maximum of 420 mg per week.
- Treatment will be administered in 28-day cycles.
Principal Investigator
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