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10 Things You Should Know About Sickle Cell Disease
According to the Centers for Disease Control and Prevention, sickle cell disease affects about 100,000 people in the United States. Learn 10 things you should know about sickle cell disease.
Sickle Cell Trait
A person with sickle cell trait inherits one gene to make normal hemoglobin and another gene to make some sickle cell hemoglobin. Hemoglobin is the part of the red blood cell that carries oxygen to different parts of the body. Sickle cell trait is not a disease and will never turn into a disease.
Sickle Cell Trait and Disease in 2025: Primer for the Primary Care Provider
Save the date for the Sickle Cell Trait and Disease Symposium! This symposium aims to educate primary care providers (PCPs) and other health care professionals regarding the diagnosis and management of sickle cell trait and sickle cell disease (SCD).
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Sickle Cell Disease
Sickle cell disease is a lifelong, inherited blood disorder that affects how oxygen flows through the body—causing pain, anemia, and serious complications. Learn about symptoms, treatment options, emergency care, and how to support your child’s health every step of the way.
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Sickle Cell Disease & Bone Marrow Transplant
The Comprehensive Sickle Cell and Thalassemia Program at Nationwide Children’s Hospital currently cares for 370 patients with sickle cell disease, ranging from birth to age 21. Learn when you should refer a patient with Sickle Cell Disease for BMT.
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Bone Marrow Transplantation Offers Hope for Extreme Cases of Sickle Cell Disease
Two-thirds of the patients who receive bone marrow transplants (BMT) at Columbus Children’s Hospital are treated for cancer conditions. The remaining BMT patients undergo the procedure for a variety of genetic disorders, including sickle cell disease.
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Sickle Cell and Thalassemia Program
The Comprehensive Sickle Cell and Thalassemia Program is home to over 280 children, adolescents and young adults, with sickle cell anemia and other disorders of hemoglobin including beta thalassemia, emphasizing primary, secondary and tertiary prevention and treatment using a multidisciplinary team
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Nationwide Children’s Hospital Becomes Authorized Treatment Center for Sickle Cell Gene Therapy
Nationwide Children’s Hospital has been designated an authorized treatment center for CASGEVY™ (exagamglogene autotemcel (exa-cel)), a gene therapy for the treatment of sickle cell disease.
Blog
What is Sickle-Cell Disease?
Sickle cell disease affects millions worldwide, causing painful complications and long-term health risks. From recognizing breathing symptoms to advocating for awareness and better care, discover how families and communities can support those living with SCD.
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Sickle Cell Patients Should Be Better Monitored for Constipation Prevention
Not all patients with sickle cell disease receive laxatives after being treated with narcotics, despite recommendations from a collaborative panel of pediatric experts.
Sickle Cell Disease and Spleen Crisis
Sickle cells can block the blood vessels leading out of the spleen. When this happens, blood stays in the spleen instead of flowing through it. This causes the spleen to get bigger, and the blood counts to fall.
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Massage Therapy Helps Manage Pain in Children with Sickle Cell Disease
Massage offers both physical and psychological benefits and is used at Nationwide Childrens Hospital in many areas including Rehabilitation, Physical Medicine and in patients who have received organ transplants, just to name a few.
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Sickle Cell Disease and Pain
Pain is a common problem for children with sickle cell disease (SCD). Sickled cells have a hard time moving through small blood vessels. They can pile up and clog the vessels, keeping oxygen from getting to certain parts of the body. This causes pain.
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Sickle Cell Disease and Stroke
Children with sickle cell disease (SCD) are at risk of having strokes. A stroke happens when the blood flow to or in the brain is blocked. This blockage slows down or stops oxygen to the brain. This can cause damage to the brain.
Blog
Sickle Cell Treatment: What Does It Mean for Patients?
Something exciting happened in December 2023, when the U.S. Food and Drug Administration approved a gene therapy for the treatment of sickle cell disease in adult and pediatric patients 12 years and older who require regular red blood cell transfusions. Nationwide Children’s Hospital is one of a handful of facilities in the United States that is certified to have the advanced facilities and specially trained staff which are needed for the administration of the therapy.
Sickle Cell Disease (SCD) and Acute Chest Syndrome (ACS)
Sickle cell disease is an inherited blood disorder. Acute chest syndrome is a group of symptoms that occurs when sickled cells clump together in the lungs.
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Sickle Cell Disease and Fever
Children with sickle cell disease (SCD) are more likely to get infections, especially bacterial infections. The spleen helps to fight infections. In patients with sickle cell disease, the spleen does not work as well. Fever may be the first and only sign of infection.
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Nationwide Children’s Hospital Delivers its First Infusion of CASGEVY™ for Patient with Sickle Cell Disease
Nationwide Children’s Hospital delivered its first commercial infusion of CASGEVY™ to 17-year-old Carlos A. from Dayton, Ohio. Today, Carlos is thriving at home, pain-free.
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SCOUTS Program
The Sickle Cell OUTreach in Schools (SCOUTS) Program supports children with sickle cell disease by providing the care and services they need – right at school.
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New suits brighten outlook for young sickle cell patients
John Martin (Columbus, 43224) receives blood transfusions every four weeks and has done so since he was 4 years old. The 21-year-old continually smiles warmly and hopes to be healthy enough to land a job, and also coach basketball, in the future.
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Hematologic Disorders
Hematologic disorders are conditions found in the blood and blood forming organs. This includes blood cell cancers, genetic disorders, anemia, HIV related conditions, sickle cell disease, and complications do to chemotherapy treatment or transfusions.
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Nahata Lab
Under the direction of principal investigator Leena Nahata, MD, the Nahata Lab focuses on improving reproductive and psychosocial outcomes in pediatric populations at risk for infertility. Learn more about the Nahata Lab and explore featured news and publications as well as information about current studies.
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Apheresis
We offer therapeutic apheresis for children and adults with a variety of conditions, including sickle cell disease, kidney disorders, neurologic conditions, cancer and graft-versus-host disease. Apheresis treatments offered include red cell exchange, therapeutic plasma exchange, leukopheresis and extra corporeal photopheresis.
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Interprofessional Education and Grand Rounds Update
- Upcoming Conferences, including Sickle Cell Trait and Disease: Primer for the Primary Care Provider
- Pediatric Grand Rounds
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Meet Our Fellows
Learn more about the Pediatric Pulmonary fellows training at Nationwide Children's Hospital.
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Transcranial Doppler (TCD) Ultrasound
Children with sickle cell disease are at risk for stroke. Transcranial (trans-CRANE-ee-ul) Doppler (TCD) ultrasounds help predict that risk. A TCD measures how fast blood is flowing to the brain. When blood flows faster than it should, there is a higher risk for a stroke.
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Creary Lab
The Creary Lab, led by Susan Creary, MD, MSc, focuses on improving outcomes of children, adolescents and young adults with sickle cell disease (SCD).
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Research for Rare Disease: Giving Hope to Families Who Are Searching for Answers
According to the Centers for Disease Control (CDC), 30 million people in the United States have a rare disease—and about half of them are children. Sometimes rare diseases are caused by unique mutations, or changes, in a child’s genes.
Blog
Stem Cell Transplant: Who Can Benefit and Who Can Be the Donor?
A stem cell transplant is a treatment that involves infusing hematopoietic (blood-forming) stem cells from a donor into a recipient. The collection of infused stem cells is called the stem cell “graft.”
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Reynoldsburg Family to Meet Members of Congress and Share Story of Bone Marrow Transplant to Cure Sickle Cell
The afternoon of June 18, 12-year-old Kimmi Desir of Reynoldsburg begins the field trip of a lifetime. Kimmi, a patient at Columbus Children’s Hospital where she received a bone marrow transplant for sickle cell disease, will participate in the June 19-20 National Association of
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Interprofessional Education and Grand Rounds Update
- Upcoming Conferences
- Pediatric Grand Rounds
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Therapies
The Gene Therapy Center of Excellence has dosed over 100 therapies since it's inception. We are proud to have been the leading institutions to discover and develop two of the currently approved gene replacement therapies, Elevidys and Zolgensma.
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Benjamin Kopp Named Nationwide Children’s Hospital’s Chief of Pulmonary, Sleep Medicine and Cystic Fibrosis
Benjamin Kopp, MD, MPH, ATSF, FAAP, has been named chief of the Division of Pulmonary, Sleep Medicine and Cystic Fibrosis at Nationwide Children’s Hospital, effective March 2, 2026.
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Nationwide Children's Patient Serving as Ohio's 'Champion Across America'
Childrens Miracle Network has named Kimmi Desir, 13, of Reynoldsburg, OH, as Ohio's Champion Across America.Kimmi, a sickle cell anemia patient, will join other child ambassadors from every state as part of the Childrens Miracle Network program, Champions Across America, presented by Walmart and
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Psychology
Pediatric Psychology experts provide care to children who have a brief or long-term medical condition. Behavior assessments and intervention services for children and their families helping in learning positive coping skills and ways to manage their physical condition.
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Bridging Our Patients from Hospital to Home
Cardiopulmonary rehabilitation is a medically supervised, individually tailored exercise and education program. It is designed to help your child feel better, increase endurance, and improve quality of life.
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Interprofessional Education and Grand Rounds Update
- Upcoming Conferences
- Pediatric Grand Rounds
- Project ECHO
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Hematology and Oncology
2222 Cherry Street
Suite 2800
Toledo, OH, 43608
(419) 251-8210
Click to learn more.
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PECARN
PECARN is the first federally-funded multi-institutional network for research in pediatric emergency medicine in the United States.
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Regional Outpatient Clinics
We are dedicated to providing comprehensive care, including diagnosis, treatment, long-term management and related services at our regional locations.
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Interprofessional Education and Grand Rounds Update
- Upcoming Conferences
- Pediatric Grand Rounds
- Project ECHO: Obesity, Rumination and Family ECHO
- MOC Part 4 Credit
- Lounge and Learn
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Newborn Screen Blood Test
The Newborn Screen Blood Test checks to see if your baby has certain disorders.
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Guidelines Highlight Key Differences Between Child and Adult Stroke
Stroke in children is not as rare as once thought and the symptoms do not mirror stroke in adults. In its first scientific statement on the topic, the American Heart Association/American Stroke Association addresses treatment, symptoms and risk for stroke in infants and children.
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Hematology Oncology Outpatient Clinic Mansfield
Find out more about the Hematology and Oncology Outpatient Clinic located in Mansfield, Ohio.
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News Archive
$13.1 Million Innovation Grant Expands Pediatric Health Care for Underserved Children The State of Ohio, Partners for Kids, Nationwide Children’s Hospital and Akron Children’s Hospital unite to expand innovative model of health care delivery for underserved children (June 18, 2012).
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Childhood Cancer Awareness Month
Learn how Nationwide Children's Hospital is participating in Childhood Cancer Awareness Month.
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Cardiopulmonary Rehabilitation Program
Our program is a medically supervised, individually tailored program consisting of exercise and education to help patients feel better, increase endurance and improve their overall quality of life.
Blog
Infection Prevention After a Bone Marrow Transplant
A weak immune system makes a patient more vulnerable to infection and taking away medications early to boost the immune system may help prevent or treat infections, but may also raise the risk of GvHD.
Strokes in Children
A stroke happens when the blood flow in or near the brain is suddenly blocked or cut off. It can cause permanent injury to the part of the brain that is not getting blood. Sometimes a stroke can lead to bleeding in the brain.
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Comprehensive Pain Services
Comprehensive Pain Services offers a variety of treatments to meet the individualized needs for many patients, including acute and regional pain, outpatient pain, palliative care, advanced illness management and integrative therapies.
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Jaundice in Children
Jaundice is a common condition in newborns that occurs when a yellow pigment (bilirubin) cannot be removed from the body fast enough and levels in the blood become too high. The buildup of bilirubin causes the skin and the white part of the eyes to appear yellow. Most cases clear without treatment.
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Survivorship Care
At Nationwide Children’s Hospital, survivorship care is broken into three specific clinics tailored for children with different survivorship needs.
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Stroke Clinic
The Stroke and Vascular Anomalies Clinic at Nationwide Children’s offers a comprehensive and multi-disciplinary evaluation to all children with stroke or at-risk of stroke.
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Fifth Disease (Erythema Infectiosum)
Fifth disease is a mild illness caused by a virus. Symptoms include a blotchy rash that begins on the cheeks and spreads to the arms, legs and torso.
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Training Opportunities
Nationwide Children's Hospital offers 9 unique fellowship experiences related to pediatric psychology.
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Blood Disease Research Affinity Group (BDRAG)
The Blood Disease Research Affinity Group (BDRAG) promotes cutting-edge collaborative research among clinical and research faculty and trainees working on blood, vascular science and related disciplines at Nationwide Children’s and The Ohio State University to positively impact the prevention and care of childhood blood diseases. BDRAG also aims to increase awareness of blood disease research on these campuses and elevate educational opportunities for trainees.
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Dr. Patrick Gallagher of Yale University Named Director of Perinatal Research Center at Nationwide Children's Hospital
Patrick Gallagher, MD, from Yale University has been named the new director of the Center for Perinatal Research in the Abigail Wexner Research Institute at Nationwide Children's Hospital.
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Spleen Injury
This Helping Hand™ covers spleen injuries. Due to where the spleen is in the body and its size, it can get injured easily. Learn what to expect if your child has a spleen injury.
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O'Brien Wynkoop Lab
Under the direction of Nicole F. O'Brien, MD, and Hunter Wynkoop, MD, the O'Brien Wynkoop Lab exists to explore global health research with a major focus on severe malaria, one of the leading causes of pediatric death and long-term morbidity on the African continent.
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Medical Identification (ID)
A medical identification is a piece of jewelry that has a medical symbol and states a health condition. It can be a bracelet, necklace or sports band.
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Signs of Stroke in Children
In children and teens, stroke shares symptoms with many health problems that occur far more commonly. When these signs suddenly occur in some combination, the suspicion for stroke is much greater.
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Bronchiolitis
This Helping Hand™ covers bronchiolitis, which is an infection of the small airways (bronchioles) caused by a virus. The most common viruses that cause it are RSV, para influenza virus, rhinovirus (common cold), human metapneumovirus and adenovirus. Bronchiolitis is also often called "RSV infection."
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Massage Therapy
A leader in pediatric massage therapy, Nationwide Children’s is one of the only children’s hospitals to staff a department of full-time, licensed massage therapists.
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Massage Therapy: Here to Help
Having a child in the hospital is stressful, especially in the long, cold winter months. At Nationwide Children’s, licensed massage therapists provide soothing, therapeutic touch for kids of all ages—and comfort for parents, too—helping reduce stress, ease anxiety, and bring a few peaceful moments to even the hardest days.
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Acute and Regional Pain Service
The Acute and Regional Pain Service is a dedicated team of physicians and advance-practice nurses that specializes in managing pain in infants, children and young adults who are hospitalized or having surgery.
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Splenectomy
This Helping Hand™ talks about what a splenectomy is, why your child may need one, and how to care for a patient who has had one.
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Impaired Spleen Function
The spleen is an organ that helps prevent and control some infections. Asplenia is when you don’t have a spleen.
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O'Brien Lab
The O'Brien Lab, led by Sarah O'Brien, MD, MSc, focuses on the intersection between women’s health and hematology.
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Pediatric Psychology Track
Learn about the diverse Pediatric Psychology track offered through Nationwide Children's Hospital.
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NFL Charities Awards More Than $1.6 Million in Sports Medical Research Grants
NFL Charities, the charitable foundation of the National Football League owners, has awarded more than $1.6 million in grants to support sports-related medical research at 16 organizations, the NFL announced today. Of these grants, $988,224 will go to studying concussion prevention and treatment.
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2024 Marathon Patient Champions
COLUMBUS, Ohio – The Nationwide Children’s Hospital Columbus Marathon & 1/2 Marathon is pleased to announce the 2024 “Mile Champions” who will represent 24 of the 26 miles on the course during the October event.
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Nationwide Children’s Hospital Celebrates a Decade of School Health Services, Impacting more than 58,000 Ohio Students
Nationwide Children’s Hospital is celebrating a decade of life-changing health care services available where students spend most of their time – at school. Since 2015, the hospital’s school-based health centers have helped more than 58,000 students across central Ohio receive vital services during the school day.
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Wolfe Associates, Inc. Pledges $2 Million to Nationwide Childrens Hospital Establishing Two Newly-Named Fellowships
Recently, Wolfe Associates, Inc. donated $2 million to Nationwide Children’s Hospital establishing two fellowships – The Wolfe Associates, Inc. Fellowship in Pediatric Oncology and The Wolfe Associates, Inc. Fellowship in Advanced Cardiac Noninvasive Imaging (Echocardiography).
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Interdisciplinary Medical Clinics
Our pediatric psychologists and neuropsychologists act as integral team members with many medical teams at Nationwide Children's Hospital.
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Nationwide Children’s Hospital Columbus Marathon & ½ Marathon Announce 2019 Patient Champions
To help fund the lifesaving research and care taking place at Nationwide Children’s, marathon and ½ marathon participants are encouraged to fundraise as “Children’s Champions.”
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Psychology and Behavioral Health
Phone: (567) 368-1311
Fax: (419) 794-7261
Click to learn more.
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Fever
In this Helping Hand™, we discuss fever, which is an increase in the body’s temperature above the normal range. Most doctors agree that a temperature over 101° F is a fever. Fevers lower than 101° F don't need to be treated unless your child is uncomfortable or has a history of febrile seizures.
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School Health Services
Our providers work on-site at schools across Ohio to provide primary care services, mental health counseling, asthma therapy care, vision care, dental care and more.
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Oral-GI Microbiology Research Affinity Group
The Oral and GI Microbiology Research Affinity Group (OGM RAG) at Nationwide Children’s Hospital will bring together like minded clinicians and basic scientists that are actively involved in research in oral and gastrointestinal microbiology as it affects human disease.
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Sore Throat (Viral)
If your child has a sore throat with any of these symptoms, it is likely due to a virus.
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Dehydration
There are many reasons why children can get dried out or dehydrated. A child can lose too much liquid from the body from diarrhea, vomiting or fever. If the child has mouth sores or a bellyache, they may refuse to drink enough. Babies and younger children are at greater risk.
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Diarrhea
Diarrhea (loose, watery bowel movements) is a common problem in young children. It is usually caused by a virus. It can also be caused by bacteria, something that the child eats or drinks (like too much fruit juice) or starting a new medicine. It rarely means a child has a serious illness.
Rotavirus
Rotavirus (ROE-tuh-vie-russ) is a contagious illness caused by a virus.
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Strep Throat (Bacterial)
Most sore throats are caused by viruses. Strep throat is a contagious sore throat that comes on suddenly and is caused by bacteria (germs) called streptococci, or strep for short. Antibiotic medicine must be given as soon as possible to prevent the strep germs from spreading in the body.
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Research Experience
Fellows are expected to have a hypothesis driven research project as their main scholarship activity during fellowship. This can be a clinical, translational or basic science research project.
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Influenza
Influenza, also known as the flu, is an illness caused by a virus. A child who has the flu may have some or all of these symptoms: high fever, headache, dry cough, sore throat, runny or stuffy nose, muscle aches, tiredness, stomach pain and diarrhea. Antibiotic medicines will not help cure the flu.
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Vomiting
Vomiting (throwing up) is most often caused by a virus or stomach bug. Some serious illnesses may also cause vomiting. Vomiting caused by a virus usually lasts only a couple of days. It can often be treated at home.
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Wagner Lab
The Wagner Lab works to improve the actionability and throughput of clinical variant interpretation. The team researches and develops methods, tools and standards for the exchange and application of biomedical evidence informing genomic variant interpretation.
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Neuropsychology Track
A primary goal is to prepare students for later careers, leadership, and board certification in Clinical Neuropsychology.
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2020 Nationwide Children’s Hospital Championship announces record-setting $2,670,000 charitable donation
Tournament officials announced today that the 14th playing of the Nationwide Children’s Hospital Championship, concluded August 23, 2020, at The Ohio State University Golf Club - Scarlet Course, raised a total of $2,670,000 for central Ohio charitable organizations, including $2,500,000 for pediatric cancer research and treatment at Nationwide Children’s Hospital.
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Temperature: Digital and Glass Thermometers
Learn how to use all three kinds of thermometers for your child.
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Physician Careers
Nationwide Children’s Hospital is always looking for excellent board certified and board eligible pediatric physicians to join our Medical Staff.
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Partners in Care, Partners in Hope
The Family Advisory Council at Nationwide Children's Hospital is proud to award an annual recognition for excellence in family-centered care. Learn more about the award and the most recent recipient.
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Meet Our Fellows
First Year Fellows Aviva Beleck, MD Medical School: Renaissance School of Medicine at Stony Brook University (Stony Brook, NY) Pediatric Residency: Case Western Reserve/Rainbow Babies and Children's Hospital (Cleveland, OH) Allysen Dubisky, MD Medical School: Michigan State University (East
Careers
Join our team and discover your passion for what’s possible in providing best outcomes for children.