Wagner Lab
The Wagner Lab works to improve the actionability and throughput of clinical variant interpretation. The team researches and develops methods, tools and standards for the exchange and application of biomedical evidence informing genomic variant interpretation.
Genomic medicine, the process of translating observed changes in patient DNA into actionable clinical findings, requires many hours of effort from variant scientists and clinical lab directors in the evaluation of each case. The majority of this time is spent on aggregating evidence relevant to observed variants and applying that evidence in the context of other medical observations about a patient. Methods are needed to streamline this process by collecting, identifying, and prioritizing the most relevant evidence given the clinical context for a patient.
To achieve these aims, the Wagner Lab coordinates with the interdisciplinary clinical and scientific expertise at the Steve and Cindy Rasmussen Institute for Genomic Medicine at Nationwide Children’s Hospital to target key areas for growth and application of the Institute’s clinical evidence databases. The lab team also collaborates with multiple international genomic knowledge sharing consortia to develop these methods, standards and tools. These consortia include the Clinical Genome Resource (ClinGen), the Global Alliance for Genomics and Health (GA4GH) and the Variant Interpretation for Cancer Consortium (VICC). Their collaboration with these groups helps them build and standardize impactful data sharing capabilities, multiplying the benefit of their applied research at the Institute for Genomic Medicine.
Join the IGM Team
The team at the Institute for Genomic Medicine is growing. Click the link below to view current job listings and to learn more about careers at Nationwide Children's Hospital.
