Das Lab

Nationwide Children's Hospital Medical Professional

Jayajit Das, PhD
Principal Investigator

Dr. Das is a PhD and principal investigator for the center. Jayajit’s lab uses theoretical and computational approaches based on statistical physics to uncover basic mechanistic principles underlying our innate and adaptive immune response. Obtaining such mechanistic principles from experimental observations alone is often difficult because the pertinent processes include co-operative dynamic events with many participating components. A further complication that confounds intuition is stochastic fluctuations in these systems with small numbers of molecules. However, by synergistically integrating observations from experiments with transgenic animals, single molecule techniques and imaging studies probing molecular events in live animals with these theoretical and computational approaches we can provide system-level understanding into such complex systems. The mechanistic insight gained from such studies not only will help develop future experiments to unravel basic principles of our immune system, but may also help envision therapeutic strategies for infectious disease and autoimmune disorders.

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Darren Wethington, BS
Graduate Research Associate

Darren is a graduate research associate for the Das Lab in the Battelle Center for Mathematical Medicine. He graduated from The Ohio State University in 2016 with a BS in Chemical and Biomolecular Engineering. He is currently in the Biomedical Sciences Graduate Program at OSU. 

Darren's roles include designing and applying systems of ODEs and stochastic simulations to study immunological systems, including signaling networks, host-pathogen viral dynamics, and bacterial co-infection dynamics. He was named the 2018 Outstanding Research Assistant at Nationwide Children's.

In his free time, Darren enjoys playing drums, bass, and guitar, watching football, playing euchre and exploring new restaurants and bars.

Rajdeep Kaur Grewal

Rajdeep Kaur Grewal, MSc
Post Doctoral Scientist

Rajdeep is a post doctoral researcher, working on computational modeling of NK cell signaling to interrogate mechanisms of signal integration in human NK cells, which play a crucial role in innate immune system response against transformed or infected cells. She completed her MSc in Applied Mathematics from Calcutta University, Kolkata, India. She submitted her PhD thesis, titled “Studies on Biological Networks” in Applied Mathematics, Bose Institute, Kolkata, India. Her aim is to understand the responses of NK cells against different virally infected target cells and tumor cells by combining mathematical modeling and available experimental data from single-cell imaging experiments.

In her free time, Rajdeep likes listening to music.

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Nathanael Cox, PhD
Postdoctoral Research Scientist

Nathanael Cox, PhD, is a postdoctoral research scientist. Dr. Cox’s research interests focus on applying tools and techniques developed in mathematics to problems in immunology. With recent innovations allowing immunologists to ascertain spatial data from tissue samples, topological data analysis will be a very important tool for interpreting this new information. 

Dr. Cox earned his doctoral degree in Mathematics at Purdue University. He studied applied topology, specifically topological data analysis, and received a concentration in computational science and engineering.