The Bedrosian Lab is interested in genetic mechanisms that shape the developing brain and contribute to neurodevelopmental disease.
The Chaudhari Lab is interested in developing, implementing and evaluating strategies to improve the integration of timely genetic diagnosis into clinical care, emphasizing that pediatric genomic medicine is a vital component of a learning health system.
The Hester Lab utilizes a multidisciplinary approach in our research that encompasses genomic medicine, neuroscience, stem cell biology, biochemistry and molecular genetics to investigate the dynamic nature of the developing brain both in the context of health and neurological disease.
The Koboldt Lab analyzes genomic data from several translational research studies at the Steve and Cindy Rasmussen Institute for Genomic Medicine at Nationwide Children’s Hospital to study the genetic basis of conditions that affect children, particularly rare diseases, epilepsy and pediatric cancers.
The Lauber Lab examines how microbes affect health. Maturation of the microbiome in children is important for maintaining healthy host-microbe interactions throughout life.
The Miller Lab’s research efforts focus on the characterization of immune cell infiltration in pediatric brain tumor samples using state-of-the-art technologies including transcriptome sequencing, single cell RNA-sequencing and spatial multiplex protein profiling.
Under the direction of Prajwal Rajappa, MD, MS, the Rajappa Laboratory at the Steve and Cindy Rasmussen Institute for Genomic Medicine focuses on precision medicine and immunotherapy for patients diagnosed with central nervous system (CNS) tumors.
The long-term goals of the Stottmann Lab are to understand the genes and molecular mechanisms guiding normal development of both the brain and face.
The Wagner Lab works to improve the actionability and throughput of clinical variant interpretation. The team researches and develops methods, tools and standards for the exchange and application of biomedical evidence informing genomic variant interpretation.