Miller Lab
In recent years, next-generation sequencing has greatly increased our knowledge of genomic and transcriptomic alterations likely associated with many diseases. The Miller Lab’s primary research efforts focus on the characterization of immune cell infiltration in pediatric brain tumor samples using state-of-the-art technologies including transcriptome sequencing, single cell RNA-sequencing and spatial gene expression profiling. In these efforts, its team seeks to parallel studies in adult cancers in an effort to explore the similarities and differences in the pediatric brain tumor setting. In addition, the lab’s research will be particularly important for comparing primary to recurrent tumors, detecting progression-related events, and identifying patients who are likely to respond to emergent immunotherapy modalities such as oncolytic viruses or personalized vaccines.
Dr. Miller is also director of the Genomic Services Laboratory, a core resource for investigators at Nationwide Children’s Hospital. Through these efforts, she has several collaborations across Nationwide Children’s Hospital and The Ohio State University in neuro-oncology, epilepsy, infectious disease, and immunology with a primary focus on single cell RNA-sequencing.
