Artomov Lab
Integration of multiple types of biomedical data provides exciting opportunities for assessing individual disease risks and predicting health outcomes. We are aiming to leverage systems genetics approaches to better understand mechanisms underlying time and severity of the disease onset.
Disease risks can be roughly categorized as either inherited or acquired through environmental exposures. To assess inherited risks, we analyze genetic data and we consider longitudinal clinical data to account for non-inherited factors. By combining multiple data types and using advanced statistical methods, we hope to gain valuable insights into disease mechanisms and the timing of disease onset.
We combine large-scale clinical and genetic data from major biobanks as well as local data at Nationwide Children's with statistical analyses techniques.
Areas of Research

We aim to make genetic data and large-scale resources available to the broad community through developing creative computational solutions preserving data privacy but enabling data analysis.

We use large-scale genetic data from major biobanks as well as local data to assess individual disease risk prediction.

We analyze large-scale sequencing and genotyping data across multiple populations to broaden the diversity in genetic research.

We develop tools for identification of novel disease genes and mechanisms.
Inside the Artomov Lab
Featured Publications
- Public platform with 39,472 exome control samples enables association studies without genotype sharing
- Prioritization of disease genes from GWAS using ensemble-based positive-unlabeled learning
- Detecting biased validation of predictive models in the positive-unlabeled setting: disease gene prioritization case study
- Discordant genotype calls across technology platforms elucidate variants with systematic errors in next-generation sequencing
Our Methods and Codes
Our lab works on developing novel computational methods to advance disease gene discovery, secure genetic data sharing and integration of many omics data types. Explore our tools at: https://github.com/artomovlab
Explore the secure platform for selecting matched controls for genetic association studies with about 40,000 exomes: https://dnascore.net