Jayajit Das, PhD

My lab uses theoretical and computational approaches based on statistical physics to uncover basic mechanistic principles underlying our innate and adaptive immune response. Obtaining such mechanistic principles from experimental observations alone is often difficult because the pertinent processes include co-operative dynamic events with many participating components. A further complication that confounds intuition is stochastic fluctuations in these systems with small numbers of molecules. However, by synergistically integrating observations from experiments with transgenic animals, single molecule techniques and imaging studies probing molecular events in live animals with these theoretical and computational approaches we can provide system-level understanding into such complex systems. The mechanistic insight gained from such studies not only will help develop future experiments to unravel basic principles of our immune system, but may also help envision therapeutic strategies for infectious diseases and autoimmune disorders.

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Featured Publication

Das J.  “Physical models in immune signaling.” Systems Immunology: An Introduction to Modeling Methods for Scientists, edited by J. Das and C. Jayaparakash, 1st ed.,  CRC Press, 2019, pp. 227-250. eBook Published 09/2018.

Publications

Jayajit Das, PhD, is a principal investigator in the Steve and Cindy Rasmussen Institute for Genomic Medicine at the Research Institute and an Associate Professor of Pediatrics at the Ohio State University. He is also an investigator at the Biophysics program at the Ohio State University, and has a courtesy appointment in the Physics Department at the Ohio State University. Dr. Das's research focuses on uncovering mechanisms underlying innate and adaptive responses in higher organisms using computational and mathematical tools rooted in statistical physics and engineering in synergistic collaboration with experimental labs at the Research Institute and outside the campus.

See Jayajit Das’s Curriculum Vitae (CV)