Researchers Studying Oral Medicine During and After Radiation to Treat Newly Diagnosed DIPG and HGG
Phase: Recruiting
First Posted: January
Condition(s): Diffuse Intrinsic Pontine Glioma (DIPG), High-Grade Gliomas (HGG)
NCT Number: NCT03605550 Other Study ID Number(s): CONNECT1702
What Is the Purpose of This Study?
To learn more about the safety of the study drug has when taken during radiation. The investigators also want to learn about the effects, if any, these drugs have on children and young adults with brain tumors. For patients in the surgical cohort, levels of the drug in the tumor will be tested, as well as biological markers of the drug inhibiting its target.
Who Can Take Part in This Study?
People who may be eligible for this study:
- Are newly diagnosed with high grade glioma (HGG) including diffuse intrinsic pontine glioma (DIPG).
- Have not yet received radiation.
- For the surgical cohort, patients with DIPG are planning to undergo biopsy (but have not yet undergone biopsy) or patients with HGG who have undergone an initial surgery, for whom second surgery for debulking purposes is recommended.
- Are 1 to 21 years old.
For a full list of eligibility requirements, visit https://www.clinicaltrials.gov/study/NCT03605550
What Will Happen During This Study?
- An oral medicine will be given twice a week for 6 to 7 weeks during radiation.
- Then, after radiation, patients will take medicine twice per week for up to 26 cycles. Each cycle lasts 28 days.
Principal Investigator
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Neuro-Oncology
Our highly experienced and internationally recognized team of pediatric neuro-oncologists, neurosurgeons and neuroradiologists will care for your child by providing the most advanced and innovative treatments, while at the same time, paying careful attention to all the needs and concerns of your child and family.
High-Grade Gliomas
High-grade gliomas are fast-growing cancers that form in the brain or spinal cord. Surgery, radiation, and targeted therapies can help. High-grade gliomas are more aggressive and can grow quickly. They are the second most common type of malignant brain tumor in children.
Diffuse Intrinsic Pontine Glioma (DIPG)
Diffuse intrinsic pontine glioma, also know as DIPG, is an aggressive, malignant brain tumor that develops in a part of the brainstem called the pons.