Researchers Studying Reduced Craniospinal Radiation Therapy and Chemotherapy for Patients With Newly Diagnosed WNT-Driven Medulloblastoma
Phase: Recruiting
First Posted: February
Condition(s): Medulloblastoma
NCT Number: NCT02724579 Other Study ID Number(s): ACNS1422
What Is the Purpose of This Study?
To study how well reduced doses of radiation therapy to the brain and spine (craniospinal) and chemotherapy work in treating patients with newly diagnosed type of brain tumor called (WNT)/Wingless (WNT)-driven medulloblastoma.
Who Can Take Part in This Study?
People who may be eligible for this study:
- Have newly diagnosed with average risk medulloblastoma in the WNT subgroup.
- Are 3-21 years old.
For a full list of eligibility requirements, visit https://clinicaltrials.gov/study/NCT02724579
What Will Happen During This Study?
- 4-5 weeks after surgery, patients have craniospinal radiation therapy 5 days a week for 6 weeks.
- After radiation therapy, 1 oral and 2 IV medications are given in weeks 1, 3, 5, and 7. Treatment repeats every 42 days.
- After radiation therapy, three IV medications are given in weeks 2, 4, and 6. Treatment repeats every 28 days.
- Patients also undergo MRI throughout the trial.
Principal Investigator
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Neuro-Oncology
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Medulloblastoma
Medulloblastomas are tumors that develop in the brain, most commonly in a region called the cerebellum. The cerebellum is located next to the brainstem and controls coordination, balance and other motor skills.
Brain Tumors
Brain tumors are the most common solid tumors in children. Primary brain tumors start in the brain and usually do not spread outside the brain tissue.