Researchers Studying Oral Medication Combination After Radiation Therapy to Treat Patients With Newly Diagnosed High-Grade Glioma
Phase: Recruiting
First Posted: February
Condition(s): High-Grade Glioma
NCT Number: NCT03919071 Other Study ID Number(s): ACNS1723
What Is the Purpose of This Study?
To study how well the combination of dabrafenib and trametinib works after radiation therapy in children and young adults with high-grade glioma who have a genetic change called BRAF V600 mutation.
Who Can Take Part in This Study?
People who may be eligible for this study:
- Have newly diagnosed high-grade glioma (HGG) with BRAF V600 mutation, excluding metastatic disease.
- Patients can have BRAF V600 mutations with or without H3 K27M mutation (stratum 1 and 2 enroll patients without H3 K27M mutations and stratum 3 enrolls patients with H3 K27M mutations.
- Are 12 months to 21 years old.
For a full list of eligibility requirements, visit https://clinicaltrials.gov/study/NCT03919071
What Will Happen During This Study?
- Patients have local radiation 5 days a week for 6-7 weeks.
- Four weeks after radiation, patients will take two oral medications for 28 days in a row.
Principal Investigator
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Neuro-Oncology
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High-Grade Gliomas
High-grade gliomas are fast-growing cancers that form in the brain or spinal cord. Surgery, radiation, and targeted therapies can help. High-grade gliomas are more aggressive and can grow quickly. They are the second most common type of malignant brain tumor in children.
Brain Tumors
Brain tumors are the most common solid tumors in children. Primary brain tumors start in the brain and usually do not spread outside the brain tissue.