Targeted Pediatric High-Grade Glioma Therapy
Phase: Recruiting
First Posted: August
Condition(s): High Grade Glioma (HGG), Diffuse Intrinsic Pontine Glioma (DIPG), Anaplastic Astrocytoma, Glioblastoma, Glioblastoma Multiforme, Diffuse Midline Glioma H3 K27M-Mutant, Metastatic Brain Tumor, WHO Grade III Glioma, WHO Grade IV Glioma
NCT Number: NCT05839379 Other Study ID Number(s): CONNECT TarGeT-SCR
What Is the Purpose of This Study?
The study aims to analyze the genes in brain tumors from kids, teens, and young adults who have just been diagnosed with a severe type of brain cancer. The results will help determine if they can join a follow-up treatment trial based on the genetic changes found in their tumors.
Who Can Take Part in This Study?
People who may be eligible for this study:
For a full list of eligibility requirements, visit https://clinicaltrials.gov/study/NCT05839379
What Will Happen During This Study?
- Utilize molecular, clinical, and histopathologic data to assess eligibility for specific biologically guided treatment subprotocols among pediatric, adolescent and young adult patients with newly diagnosed HGG, including DIPG.
- Determine the percent of pediatric, adolescent, and young adult patients newly diagnosed with HGG, including DIPG, who undergo comprehensive molecular characterization across clinical molecular testing laboratories at CONNECT sites and begin treatment on a TarGeT treatment subprotocol within 10 calendar days of starting radiation therapy (RT) (if treatment involves an agent given concurrently with RT) or within 35 days of completion of RT (if treatment involves adjuvant maintenance therapy).
Principal Investigator
Principal Investigator
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Neuro-Oncology
Our highly experienced and internationally recognized team of pediatric neuro-oncologists, neurosurgeons and neuroradiologists will care for your child by providing the most advanced and innovative treatments, while at the same time, paying careful attention to all the needs and concerns of your child and family.
High-Grade Gliomas
High-grade gliomas are fast-growing cancers that form in the brain or spinal cord. Surgery, radiation, and targeted therapies can help. High-grade gliomas are more aggressive and can grow quickly. They are the second most common type of malignant brain tumor in children.
Brain Tumors
Brain tumors are the most common solid tumors in children. Primary brain tumors start in the brain and usually do not spread outside the brain tissue.