Current Studies

Below is a list of the ongoing studies currently active in the PCRN. Click on each study to learn more.

Targeting Adolescent Insomnia to Lessen Overall Risk (for Suicide) TAILOR

PI: Jeff Bridge, PhD

This study examines the effectiveness of TAILOR, an intervention comprised of cognitive-behavioral therapy for insomnia and motivational interviewing, that is designed to improve adolescent sleep.

Primary Care Algorithms for Early Identification of Young Women with von Willebrand Disease

PI: Sarah O’Brien, MD

This study compares the validity of three screening strategies to identify young women with heavy menstrual bleeding who have an underlying diagnosis of von Willebrand Disease: 1) Bleeding Assessment Tool (BAT), 2) Point of Care (POC) ferritin, and 3) combined BAT + POC ferritin.

Broad Implementation of Outpatient Stewardship (BIOS) Project

PI: Dane Snyder, MD

In this randomized control trial, five health systems will implement the BIOS Antibiotic Stewardship QI program for clinicians treating children 6 months to 12 years for Acute Respiratory Tract Infections (ARTIs) in outpatient practice settings. The study aims to implement and evaluate the implementation of the BIOS Antibiotic Stewardship QI Program. In addition, the study aims to understand barriers and facilitators to implementation and to identify factors contributing to sustaining the intervention after the study ends.

Adaptive Immune Responses to Congenital and Postnatal Cytomegalovirus Infections

PI: Masako Shimamura

Recruit healthy controls aged 0-24 months and collect blood to compare immune responses to CMV in children with postnatal CMV infection to those after congenital CMV infection (cCMV cohort enrolled separately)

COVID-19 and Pediatrics Study (CAP)

PI: Kristen Hoskinson

Given the neurologic symptoms that accompany severe acute COVID-19 infection and long-COVID, we aim to understand better the neurological substrates of complex relative to uncomplicated COVID-19, and the impact of neural involvement on broader functioning. Our study integrates MRI, neurocognitive assessment, and measurement of emotional, behavioral, and adaptive function and quality of life.

Dialog-Based Assistant Platform for Healthcare and Needs Ecosystem (DAPHNE)

PI: Emre Sezgin

The goal of this project is to improve access to community resources and reduce unmet HRSNs. We created an app-based (web and/or mobile) chatbot service for identifying unmet HRSD and connecting families with local resources through a conversational format. The chatbot app will be used via a research phone during an in-person cross-sectional study. Participants will be onboarded and given a task to maintain a natural conversation (via text) to find community resources.

DISCOVERY

PI: Judy Groner

This multicenter clinical study is designed to follow a large group of youth at-risk for T2D over 30 months and to identify differences in a variety of factors between those who do and do not develop diabetes.

Engaging Mothers in Prompting Cardiovascular Health through Sustained Behavior Change (EMPOWER)

PI: Amrik Khalsa

Our proposal will adapt previous successful interventions to test a robust, multi-dimensional Food is Medicine intervention targeting young adult mothers (20- 40y) with a school-aged child (6- 11y) from Medicaid-eligible households. Intervention components will include home-delivered medically tailored groceries, social needs screening and direct referrals, and intensive behavior counseling.

Immune Response to Influenza Vaccines

PI: Cristina Tomatis Souverbielle

Understanding the immune response of healthy children to the influenza vaccine as compared to immunocompromised children, and which biomarkers are most helpful in investigating immune response. 

Parent-focused Redesign for Encounters, Newborns to Toddlers (PARENT)

PI: Alex Kemper, MD

PARENT is a team-based approach to care that utilizes a Parent’s Coach (i.e., health educator) as part of the well-child care team to provide comprehensive and family-centered well-child care services, address concerns related to family social needs, and decrease reliance on the clinician as the sole provider of preventive care services.

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Parental Views on Safety Anticipatory Guidance in Primary Care

PI: Erin McKnight

The purpose of the study is to assess parent/guardian viewpoints on safety discussions surrounding the top 3 causes of childhood mortality by their child's medical provider. We aim to identify if parents/guardians know the top 2 causes of death in children and understand ways to protect their children from these causes, and if they want to have discussions about keeping their child safe from these causes with their child's primary care provider.

The Garden Project

PI: Amrik Khalsa

The goal of our proposed program is to reduce food insecurity and provide under-resourced communities with access to fresh fruits and vegetables, along with nutrition education. We expect to generate actionable data demonstrating the potential effectiveness of programs like this along with the feasibility, acceptability, and cost-effectiveness of delivery this program. We will partner with either Local Matters, a grocery delivery service, or OSU's Food Farmacy to recruit and support up to 500 families to purchase fresh or frozen fruit and vegetables at designated grocer locations or via mobile delivery to reduce transportation barriers that may exist due to the distance to the nearest grocery store.