Center for Childhood Cancer Research
The mission of the Center for Childhood Cancer Research is to expand the understanding of the pathogenesis of childhood cancer and to improve strategies for diagnosis and treatment.
Our areas of focus include:
- Biology and therapy of rhabdomyosarcoma and other childhood tumors
- Chemotherapy of childhood solid tumors
- Regulation of alternative pre-mRNA splicing
- Regulation and function of tumor suppressor genes
- Oncolytic viral therapy in pediatric brain tumors
- Immunotherapy and cellular therapies that harness the natural ability of the immune system to fight cancers
Affiliations and Collaborations
Inside our Zebrafish Facility: Genetic, Life-Saving Research
The Abigail Wexner Research Institute at Nationwide Children’s Hospital is home to our cutting-edge Zebrafish Facility. These tiny fish are used in multiple disciplines in thousands of laboratories around the world. Because Zebrafish are similar to humans, our researchers are able to use the system to study processes that are difficult or impossible to follow in other animals. The level of expertise and the state-of-the-art facility set us apart in this field. This research will bring hope to families and will help better treat children with life-threatening conditions and diseases. Come inside our facility and learn more about this genetic, life-saving research.
The Research Institute’s Trainee Association (RITA) was created in 2013 to help better train and prepare trainees for their “next steps.”
Step inside the Center for Childhood Cancer Research, and you’ll find clinicians and researchers collaborating under the same roof to understand pediatric cancer, how it develops and how to treat it — all while mentoring and educating the next generation of scientists. This is a team that understands collaboration is key to ambitious basic science and impactful translational research. Thanks to that approach, its researchers are responsible for some of the most groundbreaking discoveries in pediatric cancer today.
We have a purpose for every passion. Join our team and discover your passion for what’s possible in providing best outcomes for children.
Click here to view a list of our current openings at The Research Institute at Nationwide Children's Hospital.
For Patients & Families
Our hematology, oncology, and blood and marrow transplant teams treat patients with all forms of cancer and blood disorders. Our specialists participate in collaborative research across the country and around the world to bring innovative treatments to our patients.
When you light up the lawn, you brighten patients’ holidays, help us find cures and provide the world’s finest care.
Meet Our Team
Learn more about the team of principal investigators at the Center for Childhood Cancer Research.
Under the direction of Dawn Chandler, PhD, the Chandler Lab focuses on the regulation of pre-mRNA splicing and its disruption leading to pediatric cancer and spinal muscular atrophy.
Timothy Cripe Lab
Under the direction of Timothy Cripe, MD, PhD, the Cripe Lab focuses on developing and testing new, targeted therapies for pediatric solid tumors and translating those findings into clinical studies.
Learn more about Meisam Naeimi Kararoudi, DVM, PhD, and the lab staff in the Kararoudi Lab.
The Kendall Lab is focused on developing basic and translational models of pediatric sarcomas—devastating and aggressive solid tumors with limited therapeutic options. Learn more about Genevieve Kendall, PhD, and the lab staff in the Kendall Lab.
Under the direction of Benjamin Stanton, PhD, the Systems Epigenetics Group is a highly collaborative group, focusing on pediatric cancer epigenetics and genomics.
Under the direction of Ruoning Wang, PhD, the Wang Lab conducts research to understand the fundamental questions related to cell metabolism, cell cycle, and cell fate determination in various physio-pathological contexts.
Peds-ONC Immunotherapy Center
The Pediatric Ohio-New York Cancer (Peds-ONC) Immunotherapy Center’s overarching hypothesis is that, in addition to adaptive immunotherapies, innate immune mechanisms of resistance in pediatric cancers can be leveraged as cancer immunotherapeutics.
World-renowned Biopathology Center
The Biopathology Center at Nationwide Children’s Hospital serves as the only pediatric repository for pediatric solid tumor and is one of only two repositories for leukemia samples in the United States, Canada and Australia.