Center for Clinical and Translational Research
The Center for Clinical and Translational Research exists to answer questions that will improve the early diagnosis, treatment and outcomes of society’s most important pediatric diseases by combining high-quality, fact-based lab discoveries and innovative patient-based research.
Our vision is for every pediatric patient to also become a research subject. We believe it is our responsibility to the children we are privileged to care for to learn from every child so that our care for the next child with be improved.
We will promote an environment where patient, family, researcher and clinician work together to ensure that our patients are provided the latest advances in medical knowledge, interventions and therapies to improve their health now and in the future.
Meet Our Team
Learn more about director William Smoyer, MD, and his team of principal investigators at the Center for Clinical and Translational Research.
Clinical Research Services
Clinical Research Services (CRS) is designed to be a portal through which clinical investigators access streamlined coordination of services necessary to initiate clinical research projects, regardless of funding source.
Under the direction of Carlos E. Alvarez, PhD, the Alvarez Lab studies diseases of complex genetics with the goal of identifying therapeutic targets. One of its primary efforts is the development of canine-human comparative genetics in pediatric psychopathology and cancer.
Under the direction of Michael Brian Becknell, MD, PhD, the Becknell Lab studies the mechanisms responsible for kidney injury and recovery in response to urinary tract obstruction and infection.
Under the direction of Andrea E. Bonny, MD, the Bonny Lab focuses on research to inform clinical practice for adolescents at peak risk for nonmedical use of prescription opioids, as well as dictating public policy. In the same manner, the Bonny Lab seeks to inform clinical practice for AYA on contraception.
Under the direction of David R. Brigstock, PhD, the Brigstock Lab’s primary focus is on fibrosis, a pathological process in which excessively large amounts of collagenous scar material are deposited between cells of major organs and tissues.
Under the direction of Christina Ching, MD, the Ching Lab uses a mouse model of infection to understand the host response to urinary tract infection. In addition, the lab performs in vitro simulation of infection and collects human urine samples to look for differences in components of the urine in those individuals susceptible to infection.
Under the direction of Mitchell Grayson, MD, the Grayson Lab studies how allergic diseases, like food allergy and asthma, develop, how respiratory viral infections can drive that development and how allergic disease affects the antiviral immune response in the lung.
Under the direction of Bryce Kerlin, MD, the Kerlin Lab aims to discover new approaches to prevent thrombotic complications and treat kidney disease.
The Magaña Lab bridges the clinic and the laboratory by utilizing a multidisciplinary and innovative approach to advancing the field of pediatric neuroimmunology. Dr. Magaña’s clinical and research focus is on studying the age-span of multiple sclerosis—fetal and neonatal neurology, as well as childhood, adolescent and adult neurology.
Under the direction of Vanessa Olbrecht, MD, MBA, FASA, the Olbrecht Lab aims to improve pediatric pain management outcomes and reduce unnecessary opioid exposure using innovative technologies.
Under the direction of Juan de Dios Ruiz-Rosado, PhD, the Ruiz-Rosado lab focuses on understanding the cellular immune mechanisms that contribute to the resistance or susceptibility to urinary tract infections, particularly acute pyelonephritis (APN), and the development of renal scarring following APN.
Under the direction of William E. Smoyer, MD, the Smoyer Lab focuses its research around three main themes of nephrotic syndrome, one of the most common kidney diseases seen in children.
Under the direction of Eric A. Sribnick, MD, PhD, the Sribnick Lab's research focuses on how the body’s immune system responds after traumatic brain injury.
We are dedicated to the following goals:
To aggressively pursue external funding so that we may perform clinical and translational research that is evidence based and has a positive impact for the health of our children and their families
To collaborate with colleagues locally, nationally and internationally to share knowledge and generate new ideas
To provide leadership and support to all investigators in the development and implementation of their clinical and/or translational research projects
To finalize development of an existing prototypical protocol, IRB application and master study agreement for a prospective, multicenter clinical trial based at NCH, including biological sample procurement, shipping, processing and storage in a biorepository
To develop the infrastructure to facilitate creation of additional multicenter clinical trials and consortia based at NCH, including biological sample procurement, shipping, processing and storage in a biorepository
To develop a robust and durable infrastructure to ensure application of results of multicenter clinical trials (including specific mechanisms to measure and verify these improvements) to the improvement of clinical practice by pediatricians and pediatric subspecialists