Center for Cardiovascular Research
The mission of the Center for Cardiovascular Research is to conduct innovative, mechanism-based research leading to improved therapies and outcomes for pediatric cardiovascular diseases and to foster preventive strategies and promote cardiovascular health in adults.
Our Areas of Focus
- Cardiovascular Development
- Congenital and Acquired Valve Disease
- Vascular Disease and Homeostasis
- Genetics of Congenital Heart Disease
Center Extramural Grant Funding
||A pilot biorepository of patient-specific induced pluripotent stem cells for studying single ventricle heart defects
||Additional Ventures Tools & Technology Expansion Award
||2021 - 2022
|Mingtao Zhao||Maternal blood biomarker discovery for predicting ventricular growth in human fetuses with pulmonary atresia with intact ventricular septum (PA-IVS)||Additional Ventures Innovation Fund||2021 - 2024|
||An integrated human stem cell model for elucidating NOTCH signaling in myocardial-endocardial interactions in cardiac development and disease
||2020 - 2025
|Kim McBride||Functional consequences of FHC mutations in cardiac MyBPC||Case Western Reserve University/ NIH||2020 - 2025|
|Mingtao Zhao||Elucidating Mechanisms of Ventricular Hypoplasia in Pulmonary Atresia with Intact Ventricular Septum (PA-IVS) Using Patient-Derived Induced Pluripotent Stem Cells||Additional Ventures Innovation Fund||2020 - 2022|
|Kim McBride||Development of a Protocol to Risk Stratify Individuals with Single Ventricle Congenital Heart Disease Using Deep Phenotyping and Genome Sequencing||Additional Ventures Innovation Fund||2020 - 2022|
|Kim McBride||The Genetics of Cardiovascular Malformations: A Clinical Approach||Indiana University/ AHA||2019 - 2022|
||Epigenetic Mechanisms Underlying Maternal Diabetes Associated Cardiac Malformations
||2019 - 2023
|Mingtao Zhao||NOTCH Signaling in Human Vascular Development and CADASIL||AHA||2018 - 2022|
|Aaron Trask||Novel Non-Invasive Coronary Flow Patterning to Predict Early Coronary Microvascular Disease||NIH/NIBIB||2018 - 2022|
|Madhumita Basu||Mechanisms of Maternal Hyperglycemia Induced Risk of Congenital Heart Disease||AHA||2018 - 2022|
|Brenda Lilly||Mechanisms of Cardiac and Pulmonary Fibrosis in Relation to TGF-beta Signaling and miR-145 Function||NIH/NHLBI||2017 - 2022|
|Kim McBride||Center of Research Translation in Muscular Dystrophy Therapeutic Development - Muscular Dystrophy Cell and Serum Banking Core||NIH/NIAMS||2016 - 2021|
Trainees in the News
Ruth Ackah, MD: The Ohio State University Center for Clinical and Translational Science Mentored Career Development Training Program Postdoctural Award
Sathiya Manivannan, PhD: American Heart Association and Children's Heart Foundation Congenital Heart Defect Research Awards Postdoctoral Fellowship
Randaa Breikaa: North American Vascular Biology Organization (NAVBO) Vascular Biology 2020 Conference Outstanding Poster Award
Adrianna Matos-Nieves, PhD: The Ohio State University Molecular, Cellular and Developmental Biology inaugural Student Spotlight Award for Service and Engagement
Ruth Ackah, MD: The Ohio State University Department of Surgery 2020 James D. King MD, PhD Surgical Research Award
A five-year, $1.6 million training grant funds in-depth, interdisciplinary, translational and state-of-the-art research training in congenital and acquired heart disease to clinicians and basic scientists.
The Patient-Centered Pediatric Research Program prepares postdoctoral fellows to engage in independent outcomes research in child health settings and become leaders in the conduct of patient- and family-centered outcomes research.
The Integrated Research Pathway is an American Board of Pediatrics approved mechanism for pediatric residency training. Learn more about this program and the application process.
The Research Institute’s Trainee Association (RITA) was created in 2013 to help better train and prepare trainees for their “next steps.”
Research education and training is vital to the mission of the Abigail Wexner Research Institute (AWRI) at Nationwide Children's Hospital. As a top 10 free-standing pediatric research center and an academic affiliate of The Ohio State University, AWRI has an outstanding faculty dedicated to
Learn more about research and academic events going on at Nationwide Children's Hospital.
Click here to view a list of our current openings at the Center for Cardiovascular Research.
We have a purpose for every passion. Join our team and discover your passion for what’s possible in providing best outcomes for children.
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Inside the Center for Cardiovascular Research
Meet Our Team
Learn more about director Vidu Garg, MD, and his team of principal investigators at the Center for Cardiovascular Research.
Cardiovascular Research Shared Resource
The Cardiovascular Research Shared Resource is available to facilitate both basic and translational research for basic science and clinical faculty.
Under the direction of Madhumita Basu, PhD, the Basu Lab focuses on understanding the molecular and epigenetic mechanisms of how maternal adverse environment influences the normal heart development in the embryos.
Under the direction of Vidu Garg, MD, The Garg Lab focuses on identifying the genetic contributors to congenital heart defects.
Under the direction of Brenda Lilly, PhD, the Lilly Lab is interested in the fundamentals of blood vessel formation and smooth muscle differentiation.
Under the direction of Kim McBride, MD, MS, the McBride lab investigates the cause of congenital heart defects, with a focus on malformations involving the left side of the heart.
Under the direction of Patrick McConnell, MD, the McConnell’s Lab focuses on studying biological models of heart function, pathophysiology and cardiac assisting devices.
Under the direction of Aaron Trask, PhD, the Trask Lab's research focuses on studying processes involved in adverse micro- and macro-vascular remodeling in disease.