Center for Cardiovascular Research
The mission of the Center for Cardiovascular Research is to conduct innovative, mechanism-based research leading to improved therapies and outcomes for pediatric cardiovascular diseases and to foster preventive strategies and promote cardiovascular health in adults.
Our Areas of Focus
- Genetics of Congenital Heart Disease
- Molecular Mechanisms Underlying Heart and Blood Vessel Development
- Congenital and Acquired Heart Valve Disease
- Micro- and Macro-Vascular Remodeling and Aortic Aneurysmal Disease
- Cardiac Regeneration and Stem Cell Biology
Center Extramural Grant Funding
|Vidu Garg||Epigenetic Mechanisms Underlying Maternal Diabetes Associated Cardiac Malformations||NIH/NHLBI||2019 - 2024|
|Integrative Research Training Program in Pediatric Cardiopulmonary Disease (T32)||NIH/NHLBI||2023 - 2028|
|Research Experiences in Childhood Heart, Lung, and Blood Science- REACH LABS (R25)||NIH/NHLBI||2023-2028|
|A Multi-omic approach towards improving candidate gene identification and variant prioritization in patients with congenital heart disease||NIH/NHLBI||2022 - 2023|
|Deqiang Li||Cardiac regeneration by histone deacetylases||NIH/NHLBI||2022 - 2025|
|The Role of Notch Signaling in Type 2 Diabetic Coronary Microvascular Disease||NIH/NHLBI||2023 - 2027|
|Mingtao Zhao||Dissecting SARS-CoV-2 infection in Down syndrome with congenital heart defects using patient-specific iPSCs||NIH/NHLBI||2022 - 2024|
|Mingtao Zhao||An integrated human stem cell model for elucidating myocardial-endocardial interactions in cardiac development and disease||NIH/NHLBI||2021 - 2026|
|Vidu Garg||Nationwide Children’s Hospital Summer Undergraduate Research Program||AHA||2022 - 2024|
|Jihyun Jang||Histone modifier determines chamber-specific cardiomyocyte proportions from human pluripotent stem cell cardiac lineage||AHA||2023 - 2025|
|Jihyun Jang||Endocardial Zinc Transporter Regulates Ventricular Non-Compaction Cardiomyopathy||AHA||2023 - 2026|
|Deqiang Li||Hdac7 enhances adult heart repair||AHA||2021 - 2023|
|Mingtao Zhao||Precision modeling of single ventricle heart defects using patient- and chamber-specific cardiac organoids||AHA||2023 - 2025|
|Mingtao Zhao||Maternal blood biomarker discovery for predicting ventricular growth in human fetuses with pulmonary atresia with intact ventricular septum (PA-IVS)||Additional Ventures||2021 - 2024|
Join Our Team
This T32 Fellowship Program provides state-of-the-art research training in pediatric heart and lung diseases.
Click here to view a list of our current openings at the Center for Cardiovascular Research.
Rising juniors and seniors can explore science careers and experience multidisciplinary research at AWRI firsthand through a 10-week, paid summer research opportunity funded by the American Heart Association.
The Patient-Centered Pediatric Research Program prepares postdoctoral fellows to engage in independent outcomes research in child health settings and become leaders in the conduct of patient- and family-centered outcomes research.
The Integrated Research Pathway is an American Board of Pediatrics approved mechanism for pediatric residency training. Learn more about this program and the application process.
The Research Institute’s Trainee Association (RITA) was created in 2013 to help better train and prepare trainees for their “next steps.”
Research education and training is vital to the mission of the Abigail Wexner Research Institute (AWRI) at Nationwide Children's Hospital. As a top 10 free-standing pediatric research center and an academic affiliate of The Ohio State University, AWRI has an outstanding faculty dedicated to
Learn more about research and academic events going on at Nationwide Children's Hospital.
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Inside the Center for Cardiovascular Research
Meet Our Team
Learn more about director Vidu Garg, MD, and his team of principal investigators at the Center for Cardiovascular Research.
Cardiovascular Research Shared Resource Core
The Cardiovascular Research Shared Resource is available to facilitate both basic and translational research for basic science and clinical faculty.
Under the direction of Vidu Garg, MD, The Garg Lab focuses on identifying the genetic contributors to congenital heart defects.
Under the direction of Dequiang Li, MD, PhD, the Heart Development and Regeneration Lab at Nationwide Children's Hospital aims to understand the fundamental mechanisms of cardiac cell proliferation and differentiation and how signaling communications instruct specific processes.
Under the direction of Brenda Lilly, PhD, the Lilly Lab is interested in the fundamentals of blood vessel formation and smooth muscle differentiation.
Under the direction of Patrick McConnell, MD, the McConnell’s Lab focuses on studying biological models of heart function, pathophysiology and cardiac assisting devices.
Under the direction of Aaron Trask, PhD, the Trask Lab's research focuses on studying processes involved in adverse micro- and macro-vascular remodeling in disease.