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Computational Genomics
The “big data” nature of genome-based clinical tests and research studies requires advanced high-performance computing and bioinformatics platforms to rapidly analyze and interpret information.
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Genomic Services
The Genomics Services Laboratory has extensive expertise in multiple aspects of genomics analysis.
News
New Initiative Aims to Improve Diagnosis and Treatment of Children with Solid Tumors Through Molecular Analysis
The National Cancer Institute (NCI), part of the National Institutes of Health, Children’s Oncology Group (COG), and Nationwide Children's Hospital are poised to change the direction of pediatric cancer diagnosis and care. New results from international efforts to characterize pediatric cancers have led to the Molecular Characterization Initiative: a project that aims to collect, analyze, and report clinical molecular data to support COG-affiliated clinicians in choosing the best treatment for each child. This program is part of the NCI Childhood Cancer Data Initiative (CCDI).
News
1 Year In, the CCDI Molecular Characterization Initiative Has Analyzed Samples From Over 1,000 Patients
The CCDI Molecular Characterization Initiative (MCI) is a project that aims to collect, analyze and report clinical and molecular data and is currently supporting Children’s Oncology Group (COG)-affiliated clinicians in choosing the best treatment for each child through precision diagnosis. This program is part of the National Cancer Institute (NCI) Childhood Cancer Data Initiative (CCDI), a national commitment and community-wide effort to harness data in ways that speed up progress in childhood cancer. Announced last year, the MCI is a collaboration among NCI, part of the National Institutes of Health, COG and Nationwide Children’s Hospital and is the largest initiative of its kind in the United States.
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Kloczkowski Lab
Andrzej Kloczkowski, PhD's research lab interests focus on various aspects of computational molecular biology and structural bioinformatics.
News
Nationwide Children’s Hospital Announces the Steve and Cindy Rasmussen Institute for Genomic Medicine
Nationwide Children’s Hospital announced today that its nationally known genomic medicine institute is being renamed to honor the transformational support of Steve and Cindy Rasmussen.
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Clinical Laboratory
The Steve and Cindy Rasmussen Institute for Genomic Medicine (IGM) Clinical Laboratory at Nationwide Children’s Hospital provides a variety of cytogenetic and molecular genetic tests for genetic conditions and cancers.
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Lauber Lab
The Lauber Lab examines how microbes affect health. Maturation of the microbiome in children is important for maintaining healthy host-microbe interactions throughout life.
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Das Lab
Jayajit Das, PhD's lab uses theoretical and computational approaches based on statistical physics to uncover basic mechanistic principles underlying our innate and adaptive immune response.
News
Genomic Medicine, Physician Dedication Give Family Answers About Teen’s Rare Disease
Through whole exome sequencing performed in 2020 at the Steve and Cindy Rasmussen Institute for Genomic Medicine at Nationwide Children’s, one family was finally able to put a real name to their adolescent's rare disease.
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Miller Lab
The Miller Lab’s research efforts focus on the characterization of immune cell infiltration in pediatric brain tumor samples using state-of-the-art technologies including transcriptome sequencing, single cell RNA-sequencing and spatial multiplex protein profiling.
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The Biomedical Interpretation & Training Team
The Biomedical Informatics & Training Team analyzes genomic data from several translational research studies at the Steve and Cindy Rasmussen Institute for Genomic Medicine at Nationwide Children’s Hospital to study the genetic basis of conditions that affect children, particularly rare diseases, epilepsy and pediatric cancers.
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Technology Development Laboratory
Technology and applications development is an essential component of the IGM vision.
News
Saliva, Genomic Analysis Used to Identify Promising Biomarkers for Persistent Post-Concussive Symptoms in Children
In a study published in Frontiers in Public Health, researchers with the Center for Injury Research and Policy, Division of Sports Medicine, and the Steve and Cindy Rasmussen Institute for Genomic Medicine at Nationwide Children’s Hospital have demonstrated a method by which increased risk of persistent post-concussive symptoms (PPCS) in children with concussion can be identified. This could allow families and their care teams to better assess recovery time of children with concussion.
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Wagner Lab
The Wagner Lab works to improve the actionability and throughput of clinical variant interpretation. The team researches and develops methods, tools and standards for the exchange and application of biomedical evidence informing genomic variant interpretation.
News
Nationwide Foundation Pediatric Innovation Fund Making Significant Patient Impact at the Institute For Genomic Medicine at Nationwide Children's Hospital
The Nationwide Foundation today announced a new $10 million gift for the Nationwide Foundation Pediatric Innovation Fund at Nationwide Children's Hospital to help accelerate the most promising research and clinical discoveries at Nationwide Children's.
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Miller Lab Staff
Katherine E. Miller, PhD Principal Investigator Katherine.Miller@NationwideChildrens.org Katherine (Katie) Miller, PhD, is a principal investigator in the Institute for Genomic Medicine (IGM) at Nationwide Children’s Hospital and a research assistant professor of Pediatrics at The Ohio State
Specialty
Steve and Cindy Rasmussen Institute for Genomic Medicine
The Steve and Cindy Rasmussen Institute for Genomic Medicine combines a robust clinical laboratory with genome scientists and clinical geneticists to optimize patient care.
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Hester Lab Staff
Mark Hester, PhD Principal Investigator Mark.Hester@NationwideChildrens.org Marl Hester, PhD, is a principal investigator in the Institute for Genomic Medicine.
News
Nationwide Foundation Pediatric Innovation Fund Makes Sixth Annual Gift for Significant Impact at Nationwide Children’s Hospital
The Nationwide Foundation established the Pediatric Innovation Fund in 2014 and has so far contributed $60 million to it, including the gift announced today. With Nationwide Foundation’s initial $50 million to the hospital in 2006, its gifts to the hospital have now reached $110 million.
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Stottmann Lab Staff
Learn more about principal investigator Rolf Stottmann, PhD, and his dynamic team in the Stottmann Lab.
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Bedrosian Lab Staff
Tracy Bedrosian, PhD Principal Investigator / Associate Professor Tracy Bedrosian, PhD, is a principal investigator at Nationwide Children’s Hospital and an assistant professor of Pediatrics at The Ohio State University College of Medicine. Dr.
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Rasmussen Lab
The Rasmussen Lab is dedicated to investigating the role that Human Endogenous Retrovirus K (HERV-K) has in the cellular transcriptome of pediatric tumors. HERVs are ubiquitous genetic elements, resulting from ancient retroviral infections of the human genome.
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Nationwide Innovation Fund
Since 2014, the Nationwide Foundation Pediatric Innovation Fund has contributed $140 million to accelerate the most promising treatments and discoveries at Nationwide Children’s Hospital.
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Chaudhari Lab
The Chaudhari Lab is interested in developing, implementing and evaluating strategies to improve the integration of timely genetic diagnosis into clinical care, emphasizing that pediatric genomic medicine is a vital component of a learning health system.
Blog
Genes, Genetics and Genomics: Understanding What Makes You Who You Are
Genes are short sections of DNA that carry information passed down from parents to their children. This information provides the instructions that determine physical features such as eye color, hair color and height. Sometimes this information can cause diseases. View our infographic explaining genes, genetics, the genome and genomics.
News
Behavioral Health Research, Genomics Programs Highlight $10 Million Nationwide Foundation Donation to Nationwide Children’s Hospital
Behavioral health research and genomics are among several programs at Nationwide Children’s Hospital that will continue to benefit from funding as part of a new $10 million gift that the Nationwide Foundation is making through their Pediatric Innovation Fund.
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Meet Our Team
Daniel C. Koboldt, MS Principal Investigator Dan Koboldt is a Principal Investigator at the Institute for Genomic Medicine at Nationwide Children's Hospital, and a Research Assistant Professor of Pediatrics at The Ohio State University.
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Hester Lab
The Hester Lab utilizes a multidisciplinary approach in our research that encompasses genomic medicine, neuroscience, stem cell biology, biochemistry and molecular genetics to investigate the dynamic nature of the developing brain both in the context of health and neurological disease.
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Bedrosian Lab
Under the direction of Tracy Bedrosian, PhD, the Bedrosian Lab is interested in genetic mechanisms that shape the developing brain and contribute to neurodevelopmental disease.
News
Nationwide Children's Hospital Names First Chief Data Sciences Officer
Peter White, PhD, has been named the inaugural Chief Data Sciences Officer (CDSO) of the Abigail Wexner Research Institute (AWRI) at Nationwide Children's Hospital. The CDSO will lead biomedical data science initiatives to support Nationwide Children's mission as a leader in pediatric health care innovation.
Blog
Rare Disease: Finding Answers for Patients with Mysterious Conditions
For a disease to be considered “rare,” fewer than 200,000 people in the United States will be affected by it. Some rare genetic disorders can be very difficult to diagnose, and for parents of a child with a rare disease, one of the most anxious times is the period of waiting for a diagnosis.
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Chaudhari Lab Staff
Bimal P. Chaudhari, MD, MPH Principal Investigator Bimal P. Chaudhari, MD, MPH, is a principal investigator in the Steve and Cindy Rasmussen Institute for Genomic Medicine, a member of the Sections of Neonatology, Genetics and Genomic Medicine and a founding member of the Radiogenomics Research
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Featured Genetic Tests
The Steve and Cindy Rasmussen Institute for Genomic Medicine at Nationwide Children’s Hospital offers a wide variety of genetic testing options. Learn more about the tests offered, sample(s) required, and how to order testing.
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Office of Technology Commercialization
The Office of Technology Commercialization facilitates the transfer of innovations to external partners for the benefit of our community and the general public.
News
Nationwide Foundation helping Columbus’ Linden neighborhood amidst affordable housing crisis
Funding from the 2021 Innovation Fund gift will inject $2 million in capital into Nationwide Children’s Healthy Neighborhoods, Healthy Families to create single-family affordable housing units in Linden.
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Wagner Lab Staff
Alex Wagner, PhD Principal Investigator Alex.Wagner@NationwideChildrens.org Alex Wagner, PhD, is a principal investigator in the Steve and Cindy Rasmussen Institute for Genomic Medicine at Nationwide Children’s Hospital where he leads the development of tools and standards for advancing
News
Nationwide Foundation focusing on Columbus’ Linden neighborhood in 2020 Pediatric Innovation Fund gift to Nationwide Children’s Hospital
The latest $10 million gift to the Pediatric Innovation Fund, intended to help accelerate the hospital’s most promising clinical and research programs, will support the expansion of Nationwide Children’s Healthy Neighborhoods Healthy Families (HNHF) initiative into the Linden neighborhood of Columbus, as well as establish two endowed research chairs, and invest in perinatal and genomics research.
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Artomov Lab Staff
Learn more about principal investigator Mykyta Artomov, PhD, and his dynamic team in the Artomov Lab.
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Laboratory Services News & Publications
Nationwide Children's Laboratory Services produces quarterly Newsletters to keep our clients up-to-date on our tests, our research, and many other items affecting innovations in pediatric laboratory testing.
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Translational Genomic Protocols
The Steve and Cindy Rasmussen Institute for Genomic Medicine includes several translational research programs.
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Feng Lab
Under the directions of Zongdi Feng, PhD, the Feng Lab focuses on understanding the life cycle and pathogenesis of human hepatitis viruses and identifying methods to improve the outcome of diseases caused by these infections.
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Vascular Anomalies Center
The Vascular Anomalies Center at Nationwide Children’s Hospital brings together a highly skilled interdisciplinary team of pediatric specialists to provide coordinated and comprehensive care for patients with vascular anomalies.
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Sports-Related Concussion
Researchers in the Center for Injury Research and Policy work on multi-disciplinary teams to investigate several factors related to sports-related concussion including concussion legislation, recovery from concussion, and concussion education and awareness.
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Making an Impact
From design changes in consumer products to new public policy, CIRP's influence is leading the way to a safer world at the local, national and global levels.
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Physician Careers
Nationwide Children’s Hospital is always looking for excellent board certified and board eligible pediatric physicians to join our Medical Staff.
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Announcements
See the latest announcements about the Center for Injury Research and Policy including information about recent awards, publications, studies, and events.