The Nucleic Acid Extraction Team is a part of the Biopathology Center at the Abigail Wexner Research Institute at Nationwide Children's Hospital. This team supports clinical trials that require high quality nucleic acids and is focused on providing a diverse nucleic acid extraction menu to investigators, including national organizations as the Children's Oncology Group (COG), SWOG, NRG Oncology, pediatric division of the Cooperative Human Tissue Network (pCHTN), and the Experimental Therapeutics Clinical Trials Network (ETCTN).
A variety of methods are available for nucleic acid extraction from blood, tissue, buccal swabs, or saliva. Quality control to test the integrity of the DNA or RNA is performed at the investigator’s request. Each trial or project is managed separately after discussion with the investigator regarding optimal collection methods and desired downstream applications.