Onohara Lab
The Onohara Laboratory is focused on translational research, specifically in establishing complex large animal models and developing new surgical/interventional treatments. Currently, Dr. Onohara’s lab is advancing a novel transcatheter device designed to treat heart failure patients with functional mitral regurgitation. This device is engineered to reshape the dilated left ventricle and approximate the papillary muscles, thereby aiming to mitigate adverse left ventricular remodeling and concurrently correct mitral regurgitation. Furthermore, his lab is establishing an in-utero lamb model to replicate hypoplastic left heart syndrome, achieved by obstructing the mitral inflow with an expandable balloon catheter in the left atrium. The evaluation of the animal models and the new surgical/interventional devices involves the use of echocardiography, invasive hemodynamics, and cardiac MRI.
