The Chiang Lab is devoted to the design of tissue engineered trachea for the management of complex long segment airway defects. An ideal tracheal replacement will permit the replacement of diseased or absent tissue with a living construct capable of renewal and regeneration.
Despite advances in airway surgery, there are few surgical options for children suffering from long segment tracheal defects. Our goal is to define the mechanisms driving airway regeneration and apply them to the design of tissue engineered tracheal grafts.
Our lab is translational, we explore the mechanisms of tracheal regeneration with computational, in vitro models and apply these discoveries to in vivo models with the intent of improving patient outcomes.