Kelly Lab
The Kelly Laboratory is focused on improving the care of children born with congenital heart disease, with a particular interest in single ventricle heart disease. Patients with single ventricle heart typically require three open heart surgeries before 4 years of age, in what is termed Fontan palliation. While Fontan palliation is lifesaving, we now appreciate patients cannot expect a normal quality and duration of life. The dual appointment of John Kelly, MD, as a pediatric cardiologist and principal investigator in the Center for Regenerative Medicine allows for conduction of research along the translational continuum. Current projects focus on the development of a chronic large animal model of Fontan palliation to evaluate curative solutions for single ventricle heart disease and to study the end-organ complications induced by Fontan hemodynamics. Additionally, Dr Kelly is the co-director of the Pediatric Fontan clinic concentrated on standardizing and advancing the management of patients living with Fontan physiology.
Featured Publication
- Kelly JM, Hu Z, Takaesu F, Watanabe T, Storrs J, Blais B, Yuhara S, Morrison A, Nelson K, Ulziibayar A, Heuer E, Anderson C, Jimenez M, Leland J, Malbrue R, et al. Investigation of a chronic single-stage sheep Fontan model.JTCVS Open. 2024;21:268–278.
Featured Research Projects
Collaborative grant with Christopher K. Breuer at Nationwide Children’s Hospital and Liming Pei at Children’s Hospital of Pennsylvania.
Collaborative grant with Patrick Boyle at the University of Washington.
Collaborative grant with Christopher K. Breuer and David M. Brigstock at Nationwide Children’s Hospital and Michael Davis at Emory University.
