The BCR is a laboratory and biorepository within the Biopathology Center (BPC) at Nationwide Children's Hospital and is accredited by the College of American Pathologists (CAP) Biorepository Accreditation Program (BAP). The BCR supports multiple cancer genomics projects for the Center for Cancer Genomics (CCG) at the National Cancer Institute (NCI) and other contracted entities.
Nationwide Children’s Hospital was selected to serve as the BCR for The Cancer Genome Atlas (TCGA) Project because of the BPC's reputation for quality biobanking and tissue processing. Due to the modularity of the BCR’s system and high-quality output, the BCR has expanded into other projects. Currently, the BCR serves as the Center for Cancer Genomic's (CCG) Biorepository and Archive (CBA), as well as serving as a Biospecimen Processing Center (BPC) for numerous projects. These projects include the Cancer Driver Discovery Project (CDDP), Clinical Trials Sequencing Project (CTSP), Adjuvant Lung Cancer Enrichment Marker Identification and Sequencing Trials (ALCHEMIST), Exceptional Responders (ER) Initiative, Burkitt Lymphoma Genome Sequencing Project (BLGSP), HIV+ Tumor Molecular Characterization Project (HTMCP), and others.
More than 20 years ago, pediatric cancer pathologist Stephen J. Qualman, MD, was ahead of his time in realizing the importance of developing biobanking as a scientific discipline. A sophisticated, high-quality biobanking effort has existed at Nationwide Children’ since the late 1980s, and now serves as the biorepository for three of the NCI's National Clinical Trials Network (NCTN) Groups: Children's Oncology Group (COG), NRG Oncology* (Gynecologic Bank), and SWOG (formerly Southwest Oncology Group). The BPC also serves as a centralized clinical reference laboratory for COG, performing testing to assign patients to risk-based therapies.
*NRG Oncology is a collaborative group of the National Surgical Adjuvant Breast and Bowel Project (NSABP), Radiation Therapy Oncology Group (RTOG) and Gynecologic Oncology Group (GOG).