Clinical Pathways

Nationwide Children’s Hospital’s Clinical Pathways are peer-reviewed, evidence-based best practice recommendations for the management and treatment of medical conditions. Our goal in sharing Clinical Pathways is to standardize best practices, leading to the best patient outcomes.

About Nationwide Children’s Clinical Pathways Program

  • Our Clinical Pathways are informed by national clinical practice guidelines and a review of current literature.
  • They are meant to complement clinical judgment; they are not meant to be applied rigidly in all cases. 
  • Clinical Pathways are developed by content experts, including physician and nursing leaders from medical subspecialties, and representatives from pharmacy, respiratory therapy and other allied health practitioners.

Questions can be directed to the Clinical Pathways team by email at

Access Clinical Pathways

Diabetic Ketoacidosis

This clinical pathway explores the evaluation and treatment of patients with Diabetic Ketoacidosis (DKA) and medium-high risk for cerebral edema in an Emergency Department care setting.

Febrile Neonate 0-21 Days

This clinical pathway discusses the evaluation and mangement of a well appearing febrile infant (0-21 days old) in an Emergency Department setting.

Fecal Impaction

This clinical pathway discusses fecal impaction in inpatient settings.

Procedural Sedation

This clinical pathway discusses the use of anxiolytic, sedation, hypnotic, analgesic, and/or dissociative medication(s) to attenuate anxiety, pain, and/or motion in Emergency Department care settings.


This clinical pathway is designed to help Emergency Medicine providers reduce mortality among Emergency Department Sepsis Alert patients.