Lynch Lab
While the idea that “structure is function” is a fundamental tenant of biology, little is known about the dynamic mechanisms that maintain distinct regional compartmental structures in health or permit plasticity among otherwise distinct stem cell compartments after injury. The Lynch Lab leverages cutting-edge animal models, cell and tissue culture techniques, and transcriptomics to study region-specific cell differentiation, renewal and regenerative plasticity in the conducting airways of the lung.
Inside Lynch Lab
Our Research
Lungs have a complex structure of intricately branching airways that conduct your breath to and from specialized cellular membranes where CO2 can be exchanged for O2. While a person lives with the same lungs for hopefully many, many decades, the cells that make up those lungs have a much shorter lifetime. Luckily, lung-resident stem cells are capable of renewing multiple cell types including themselves. The Lynch Lab focuses on studying how stem cells in different parts of the lungs renew specific cell types in order to maintain the complex structure that is necessary for healthy physiologic function.
Featured Publications
- Submucosal Gland Myoepithelial Cells Are Reserve Stem Cells That Can Regenerate Mouse Tracheal Epithelium
- Depletion of Airway Submucosal Glands and TP63+KRT5+ Basal Cells in Obliterative Bronchiolitis
- Ferret Lung Transplantation Models Differential Lymphoid Aggregate Morphology Between Restrictive and Obstructive Forms of Chronic Lung Allograft Dysfunction
- Multipotent Myoepithelial Progenitor Cells Are Born Early During Airway Submucosal Gland Development
Join Our Team
The Lynch Lab is always growing. If you are interested in joining our team as a student intern, clinical research coordinator, or post-doctoral fellow, please email us with a cover letter and a CV/Resume at LynchLab@NationwideChildrens.org.
