According to the World Health Organization (WHO), more than one in 10 babies are born preterm, or before 47 weeks of pregnancy are completed. This amounts to an estimated 15 million babies born preterm each year. Preterm birth complications are the leading cause of death among children under 5 years of age globally, with one million children dying each year and many survivors experiencing lifelong complications.
The Rogers Lab aims to better understand the pulmonary and cardiac complications of premature birth and develop treatments to decrease morbidities in prematurely born infants. Many preterm births are a result of maternal inflammation, and once born, preterm infants often require oxygen therapy for survival. The combination of inflammatory stimuli results in a much more severe pathophysiology with more critical and long-lasting morbidities. In examining how this inflammation and oxidative stress in pregnancy and early life affects infants’ lung development, the Rogers Lab has identified several epigenetic markers that are affected by these adverse conditions and may be linked to further disease development. These include microRNAs, upregulation of methylation enzymes and methylation of key genes. Using both in vivo and in vitro techniques to validate findings in human samples, the Rogers Lab has identified these markers in infants diagnosed with bronchopulmonary dysplasia (BPD) and in mouse models of combined inflammatory exposures. The lab’s team is working to better understand the mechanisms driving these alterations and how they affect the morbidities observed and to identify pathways that can be targeted for interventions.
Lynette Rogers, PhD
Interim Director; Principal Investigator
Lynette Rogers, PhD, is a principal investigator in the Center for Perinatal Research in the Abigail Wexner Research Institute at Nationwide Children’s Hospital and an associate professor at The Ohio State University College of Medicine. Her NIH-funded research focuses on lung injury and growth deficits in preterm infants to better understand the consequences of premature birth and develop treatments to decrease morbidities in prematurely born infants.
Senior Research Associate
Kathryn conducts research, trains incoming students and employees and handles general lab management duties.
Senior Research Associate
Aiman maintains analytical instrumentation (LC-MS/MS, HPLC-UV, GCMS, GC) and analyzes RNA-sequencing data sets. Her research is centered on vitamin D3 metabolism and corticosteroid sensitivity in severe allergic airway inflammation.