Wang Lab
The Wang Lab has a long-term interest in understanding the fundamental questions related to cell metabolism, cell cycle, and cell fate determination in various physio-pathological contexts. The laboratory currently employs model organisms and cutting-edge tools to:
- establish a framework for understanding metabolic checkpoints during cell cycle transitions.
- delineate control mechanisms and signatures of immune cell metabolism.
- address how the altered immune metabolic landscape impacts autoimmunity and antitumoral immunity.
- determine how metabolic reprogramming during development impacts tumorigenesis and tumor immunity in pediatric cancers.
Inside Wang Lab
Featured Publications
- Asparagine restriction enhances CD8+ T cell metabolic fitness and antitumoral functionality through an NRF2-dependent stress response
- The lactate dehydrogenase (LDH) isoenzyme spectrum enables optimally controlling T cell glycolysis and differentiation
- GAB functions as a bioenergetic and signalling gatekeeper to control T cell inflammation
- Succinate dehydrogenase/complex II is critical for metabolic and epigenetic regulation of T cell proliferation and inflammation
- Inosine is an alternative carbon source for CD8+ T cell function under glucose restriction
- De novo synthesis and salvage pathway coordinately regulates polyamine homeostasis and determines T cell proliferation and function
- mTOR Is Key to T Cell Transdifferentiation
- Glutathione de novo synthesis but not recycling process coordinates with glutamine catabolism to control redox homeostasis and directs murine T cell differentiation
- Metabolic maintenance of cell asymmetry following division in activated T lymphocytes
- Proinflammatory signal suppresses proliferation and shifts macrophage metabolism from Myc-dependent to HIF1α-dependent
- Dendritic cell SIRT1-HIF1α axis programs the differentiation of CD4+ T cells through IL-12 and TGF-β1
Ongoing Research Support
| Funding | Research | Role |
| NIH/NIAID 1R01AI175004 | Decipher and target GABA metabolism and receptor-mediated signaling in inflammation and autoimmunity |
Principal Investigator |
| NIH/NCI 1R01CA247941 | Modulation of asparagine bioavailability and stress response signaling to enhance T cell robustness and maximize immunotherapy |
Principal Investigator |
| NIH/NIAID 2R01AI114581 | Dissect and target Arginine-polyamine metabolic axis in T cell mediated inflammation and autoimmunity | Principal Investigator |
| NIH/NCI U54CA232561 | Counteracting suppressive factors to effectively harness cellular and viral immunotherapies for pediatric solid tumors |
co-Investigator, |
| NIH/NCI R37CA | Optimizing Theranostic Dosimetry and Kidney Biomarkers for Alpha-Emitter Radioligand Therapy in Neuroendocrine Tumors |
co-Investigator, Zepeda-Orozco |
