Research Grants

Eunice Kennedy Shriver NICHD Cooperative Multicenter Neonatal Research Network

Funding agency: National Institute of Health/NICHD

Funding period: 4/2016-3/2021

PI: Walsh

Associated Faculty: Taylor

As part of a national consortium, the major goal of this project is to investigate outcomes of preterm birth and examine factors related to outcome.

 

Development of "the Period of Baby Crying" Educational Material and Evaluation of its Effectiveness in Prevention of Inflicted Traumatic Brain Injury

Funding agency: International-China

Funding period: 1/2018-12/2020

Site PI: Henry Xiang, MD, MPH, PhD

The aim of this study is to conduct a randomized trial of an education intervention to prevent inflicted pediatric traumatic brain injury in China.

 

A Multicenter Trial of Contrast-Enhanced Ultrasound in the Evaluation of Abdominal Solid Organ Injuries in Pediatric Trauma Patients 

Funding agency: Boston Children’s Hospital

Funding period: 1/2018-12/2019

Site PI: Jonathan Groner, MD

The aim of this study is to evaluate whether the use of ultrasound contrast can improve the sensitivity and specificity of ultrasound in diagnosing abdominal solid organ injuries in pediatric patients, thereby making it a valuable diagnostic tool.

 

Epidemiology Study of Intentional Injuries in Children with Disabilities in Beijing

Funding agency: International-China

Funding period: 1/2017-12/2019

Site PI: Henry Xiang, MD, MPH, PhD

The goal of this study is to investigate intentional injuries (child abuse) in Chinese children with disabilities in Beijing, China.

 

Opioid Prescribing Disparities in a Public Health Crisis: The Case of Pediatric Post-Surgical Pain Management

Funding agency: National Institute of Health/NIMHD

Funding period: 9/2017-8/2019

PIs: Deena Chisolm, Katherine Deans

Associated Faculty: Cooper

African American pediatric surgery patients are less likely to receive an opioid prescription for pain management at discharge than their White counterparts, and this disparity exists in the midst of a national opioid epidemic that is driving implementation of use reduction policies that could further expand disparities. This study aims to explore the inter-related impacts of policy, clinical need, and sociodemographic factors on racial disparities in postoperative discharge opioid prescribing by combining Medicaid claims and electronic medical record data with findings from a statewide opioid policy inventory.

 

Great Lakes Emergency Medical Services for Children Research Network (GLEMSCRN)

Funding agency: Health Resources and Services Administrations 

Funding period: 9/2015-8/2019

PI: Rachel Stanley, MD

Associated Faculty: Julie Leonard, Stanley

This is an infrastructures grant to support Nationwide Children’s Hospital, Children’s Hospital of Michigan and University of Michigan’s participation in the Pediatric Emergency Care Applied Research Network.

 

Center for Injury Research and Policy (Center Grant)

Funding agency: Center for Disease Control/National Center for Injury Prevention and Control

Funding period: 8/2012-7/2019

PI/Co-investigator: Henry Xiang, MD, MPH, PhD (Director for Research Core)

The Center for Injury Research and Policy of the Research Institute at Nationwide Children’s Hospital conducts research in all three core phases of injury control (prevention, acute care and rehabilitation) and serves as an academic training center for students from high school through post-graduate levels as well as for visiting international scholars. Trans-disciplinary research conducted at CIRP includes the fields of medicine, public health, epidemiology, law and criminal justice, behavioral and social sciences, biostatistics, biomechanics, ergonomics and economics.

 

Impact of Ohio’s Youth Concussion Law on Patterns of Healthcare Utilization

Funding agency: Centers for Disease Control

Funding period: 8/2017-7/2019

PI: Ginger Yang, PhD, MPH

The major goal of this study is to assess the impact of Ohio’s concussion law on changes in the patterns of healthcare utilization among youth ages 5 to 18 with diagnosed concussions.

 

Causal Inference for Treatment Effect using Observational Healthcare Data with Unequal Sampling Weights

Funding agency: National Institute of Health

Funding period: 9/2015-2/2019

PI: Henry Xiang, MD, MPH, PhD, Bo Lu, PhD

This study aims to implement propensity score based estimators with complex survey designs to gauge a treatment effect.

 

Traumatic Injury Clinical Trial Evaluating Tranexamic Acid in Children (TIC-TOC)

Funding agency: National Institute of Health/NHLBI

Funding period: 1/2017-12/2018

PI: Nathan Kuppermann/Rachel Stanley

Associated Faculty: Thakkar

The primary objective of this pilot study is to assess the overall feasibility for two subsequent, dose-finding Phase II/III seamless adaptive clinical trials evaluating the benefit of TXA in severely injured children (one for blunt torso injuries and the other for traumatic brain injuries).

 

Predicting Outcomes of Pediatric Mild Traumatic Brain Injury

Funding agency: National Institute of Health/NICHD

Funding period: 10/2012-8/2018

PI:  Keith O. Yeates, PhD

Associated Faculty: Taylor

The major goal of this study is to follow children with mild traumatic brain injury ages 8-16 years to identify early predictors of persisting injury consequences.

 

Optimal Physical and Cognitive Rest after Sports-Related Concussions

Funding agency: National Institute of Health/NICHD

Funding period: 9/2016-8/2018

PI: Ginger Yang, PhD, MPH

The major goal of this study is to determine the optimal levels of physical and cognitive rest in relation to recovery from sports-related concussions among youth.

 

Active and Passive Virtual Reality (VR) Distraction for Pain Management during Pediatric Burn Patients Dressing Changes

Funding agency: Nationwide Children’s Hospital Trauma Program

Funding period: 8/2016-7/2018

PIs: Rajan Thakkar, MD, Henry Xiang, MD, MPH, PhD

This project aims to develop and compare the efficacy of an active VR-based pain management program versus a passive VR distraction tool for pediatric burn patients during dressing changes.

 

Massive Transfusion Epidemiology and Outcomes in Children (MATIC)

Funding agency: National Institute of Health 

Funding period: 8/2016-7/2018

PI: Madsen

Associated Faculty: Julie Leonard

This is a multi-center prospective observational database for children who have an MTP activated for life-threatening bleeding. The objective of this study is to investigate the epidemiology, resuscitation practices, and outcomes in children with severe bleeding from all causes.

 

Development of a VR-Based Program for Cognitive Rehabilitation in Children with Traumatic Brain Injury (TBI)

Funding agency: Nationwide Children's Hospital Intramural Grant

Funding period: 7/2016-6/2018

PIs:  Jiabin Shen, PhD, Jonathan Groner, MD, Henry Xiang, MD, MPH, PhD

This project aims to develop an immersive virtual reality (VR)-based cognitive training program for the rehabilitation of executive functions in children with moderate to severe traumatic brain injuries.

 

GM-CSF for Immunomodulation Following Trauma (GIFT)

Funding agency: National Institute of Health/NIGMS

Funding period: 4/2011 – 6/2018

PI: Hall

This project is a multi-center interventional, open-label, dose-finding study of the drug GM-CSF for the reversal of trauma-induced immune suppression in critically injured children.

 

A National Study of Medical and Rehabilitation Services for U.S. Children with Traumatic Brain Injuries

Funding agency: Health Resources and Services Administration

Funding period: 4/2017-3/2018

PIs: Henry Xiang, MD, MPH, PhD, Jiabin Shen, PhD

To investigate the medical and rehabilitation services for U.S. children with TBI by examining disparities in medical service utilization and expenditures associated with pediatric TBI in the U.S. and identify recovery trajectories after TBI in U.S. children.