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Mapping the 3D Structure of Rhabdomyosarcoma Chromatin
In a paper published in Nucleic Acids Research Cancer (NAR Cancer), researchers from the Center for Childhood Cancer Research at Nationwide Children’s and their collaborators report a comprehensive 3D chromatin structural analysis and characterization of rhabdomyosarcoma (RMS).
News
Genomic Medicine, Physician Dedication Give Family Answers About Teen’s Rare Disease
Through whole exome sequencing performed in 2020 at the Steve and Cindy Rasmussen Institute for Genomic Medicine at Nationwide Children’s, one family was finally able to put a real name to their adolescent's rare disease.
News
Early Phase Gene Therapy Study for SMARD1/CMT2S Disease Now Enrolling
Nationwide Children's Hospital has launched a new Phase I/IIa gene replacement clinical study to evaluate the safety of a gene therapy for IGHMBP2-related diseases, specifically spinal muscular atrophy with respiratory distress type 1 (SMARD1) and Charcot Marie Tooth disease type 2S (CMT2S). SMARD1 and CMT2S are rare inherited conditions that are both caused by mutations in the IGHMBP2 gene, of which more than 60 have been found to date. SMARD1 is the most severe form of these diseases and causes muscle weakness and respiratory failure in infancy.
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Nationwide Children's Researchers Work to Transform Approach to Epigenetic Studies in Pediatric Cancer
Researchers from the Center for Childhood Cancer Research at Nationwide Children’s Hospital offer a new platform technology and proof of concept that illuminates the role of PAX3::FOXO1, a known gene fusion driving rhabdomyosarcoma.
Article
A Message from our Chief Nursing Officer (CNO)
View a message from our Chief Nursing Officer, Lee Ann Wallace.
News
Nationwide Children’s Hospital Included on Forbes’ List of ‘America’s Best Employers for Women’
Nationwide Children’s Hospital has ranked in the top 10 and as the top employer in Ohio on Forbes’ 2025 “America’s Best Employers for Women” list.
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Researchers at Nationwide Children’s Hospital Awarded PCORI Funding to Advance Suicide Prevention Efforts in Schools
Researchers at Nationwide Children’s Hospital have been approved for $16 million in research funding from the Patient-Centered Outcomes Research Institute (PCORI) to lead a study focused on reducing adolescent suicide through school-based prevention programs.
News
Understanding the Rising Suicide Risk Among Black Youth
A new study, published today in JAMA Network Open and led by Cynthia Fontanella, PhD, principal investigator for the Center for Suicide Prevention and Research at Nationwide Children’s Hospital, is the first large-scale study to examine multi-level risk and protective factors for suicide among Medicaid-enrolled Black youth with a lifetime mental health diagnosis.
News
Study Shows Text Messages Help Youth at Risk For Suicide Feel Supported After Discharge
In a study published today in the JMIR Pediatrics and Parenting, faculty at the Center for Suicide Prevention and Research (CSPR) at Nationwide Children’s Hospital described the implementation of an automated Caring Contacts texting system and found the intervention helped youth at risk for suicide feel hopeful and supported during a period of heightened risk. According to the study, this intervention and similar efforts to improve care transitions are critical to improving youth suicide prevention outcomes.
News
Nationwide Children’s Hospital - Toledo Commits Over $100 Million Investment in New Outpatient Facilities to Expand Local Pediatric Care in Northwest Ohio
Nationwide Children’s Hospital - Toledo announced today a planned $100 to $150 million investment to expand pediatric care across the Toledo region over the next five years. The investment will support the construction of two new, state-of-the-art pediatric medical facilities designed to maximize patient safety and experience, enhance care and create capacity to recruit additional providers so children in northwest Ohio can receive more care close to home.