Neonatal Lung Injury and Pulmonary Hypertension Focus Group


The Neonatal Lung Injury & Pulmonary Hypertension Focus Group is a research group dedicated to improving the health of infants with pulmonary disease through innovative basic science, clinical, and translational research.

About the Group

Investigators in the Center for Perinatal Research and The Ohio State University, led by Dr. Jennifer Trittmann, have formed the Lung Injury and Pulmonary Hypertension Focus Group. Our group consists of 6 senior faculty and 3 junior faculty, and thus is an important mechanism for research training, resulting in manuscript publishing and grant proposal applications. These meetings provide a forum for presenting current research and identifying opportunities for collaboration.


Establish a network of investigators within the Abigail Wexner Research Institute at Nationwide Children’s Hospital and The Ohio State University who are interested in lung injury and pulmonary hypertension in order to facilitate the generation of new knowledge in 4 key areas:

Areas of Interest

Pulmonary Vascular Endothelium

  • L-arginine/NO pathway
  • Adenylate Cyclase- cAMP-PDE-3 Pathway

Pulmonary Vascular Remodeling

  • Smooth muscle cell migration, proliferation, hypertrophy


  • MKP-1
  • Early biomarkers that predict outcomes and development of lung injury


  • Thioredoxin redox system

Methods Used

  • Cell culture: list type of cells
  • Animal models: list type of animals
  • Imaging: Pulmonary CT imaging, Cardiac MRI
  • Clinical tests: Pulmonary function tests, Echocardiography

Specific goals for 2014-2017

  1. We will meet approximately every 2 weeks to discuss current research activities (manuscripts and grants in preparation) and all work will be submitted for publishing and external funding.   
  2. Obtain funding for recruitment of one nationally recognized, external speaker per year to present at the Center for Perinatal Research Monthly Seminar.