Ryan Roberts, MD, PhD
Ryan D. Roberts, MD, PhD, is a physician for the Division of Hematology and Oncology at Nationwide Children’s Hospital, a principal investigator for the Center for Childhood Cancer and Blood Diseases at The Research Institute at Nationwide Children’s Hospital and a member of the Translational Therapeutics research program at The James Comprehensive Cancer Center at The Ohio State University.
Dr. Roberts is a graduate of the Medical Scientist Training Program at the Ohio State University and of the Pediatrics Residency and Pediatric Hematology, Oncology, and BMT Fellowship at Nationwide Children’s Hospital. In 2016, he joined the faculty of the Research Institute at Nationwide Children’s hospital, building on the research program that he developed as a resident and fellow.
My primary role is to coordinate and conduct the microfluiduc single cell capture experiments that produce cellular expression profiling through genomic sequencing data mining related to both our study of osteosarcoma cancer and to other diseases of collaborating labs interested in employing the use of this technology. I also fulfill a broadly supportive role for our group, exercising a proficient and diverse technical skill set in conducting experiments and compiling data as a member of our team.
I do the mouse work for Animal Tumor Core, which includes tail vein injections, tumor implantation, drug testing, tumor measuring, Xenogen scanning and more.
Graduate Research Associate
I am originally from Chicago, Illinois, and moved to Columbus in July 2016 to begin my first year in the Molecular, Cell, and Developmental Biology (MCDB) PhD program at The Ohio State University. Our lab is focused on the biology of osteosarcoma, which is the most prevalent bone cancer effecting adolescents. Osteosarcoma is unique because unlike most other cancers it only metastasizes to the lungs. My research is focused on identifying and targeting the tumor-host interactions responsible for this predilection, thereby preventing metastasis.
The past 30 years have seen remarkable improvements for many children with cancer. While the total survival rate for pediatric cancer is nearing 80% or greater for some malignancies, the survival rate for solid tumors after metastasis remains dismal. For instance, the survival rate for metastatic osteosarcoma is less than 30%. I am interested in understanding the mechanism underlying the tropism between osteosarcoma cells and lung parenchyma and how this tropism promotes metastatic growth and resistance to chemotherapy.
I am from Chennai, which is a coastal city in south India. My current research interest in the lab is understanding intra-tumor heterogeneity and studying tumor-host interactions that drive chemotherapeutic resistance and increased capacity to colonize the lung in osteosarcoma.
My research interests include Osteosarcoma research.