Kevin A. Cassady, MD
Dr. Cassady received his bachelor’s degree from Georgetown University, his medical degree from the University of Alabama School of Medicine, and his pediatric specialty training at University of Washington in Seattle. Dr. Cassady completed a post-doctoral fellowship in Molecular Virology in Dr. Bernard Roizman’s lab at the University of Chicago and then completed his pediatric infectious disease training at the University of Alabama at Birmingham (UAB) where he joined the Pediatric Infectious Disease Faculty. Dr. Cassady is an Associate Professor at the Research Institute at Nationwide Children’s Hospital and in the Ohio State University Department of Pediatrics. He is a member of both the Center for Childhood Cancer and Blood Diseases and the Division of Pediatric Infectious Diseases.
Dr. Cassady’s research focuses on how Herpes Simplex Virus (HSV) induces and modulates the antiviral immune response. By understanding how the cell restricts virus replication, his lab has developed a recombinant HSV that selectively replicates in tumor cells and can be used safely to treat brain tumors. The lab is now advancing this virus into clinical trials and are investigating ways to improve virotherapy by harnessing the antiviral immune response and directing it against the tumor.
Mohammed Ghonime, PhD, is a scientist at the Center for Childhood Cancer and Blood Diseases. Dr. Ghonime has a bachelor’s degree in pharmaceutical sciences and master’s and PhD degrees in Immunology. He completed his post-doctoral training at the Department of Microbial Infection and Immunity at the Ohio State University, he worked on developing a new platform for cancer vaccination. Dr. Ghonime has an active interest in viro-immunotherapy and the immune mediated anti-tumor response. His primary interest lies in the development of new oncolytic virus-based therapeutics and combining of oncolytic virus with other immune-, chemo-, and/or radio-therapies to establish effective treatment options for the highly resistant tumors including solid tumors and gliomas. Also, Dr. Ghonime is studying resistance mechanisms within the tumor cells and the composition of tumor microenvironment to develop combination therapy that promote the development of durable anti-tumor immunity.
I graduated with my Bachelor of Science in Biochemistry from the University of Toledo in May of 2017. After taking a year off from research, I have returned with a passion for making a difference in someone's life. Working at Nationwide Children's Hospital has given me the chance to combine this passion with science. Research affords me the opportunity to learn new techniques and be hands on while working with cells and viruses to study cancer treatment.
I work on problems related to an HSV-derived oncolytic virus (C134) and malignant peripheral nerve sheath tumors (MPNST).