Center for Childhood Cancer and Blood Diseases
The mission of the Center for Childhood Cancer and Blood Diseases is to expand the understanding of the pathogenesis of childhood cancer and to improve strategies for diagnosis and treatment.
Our areas of focus include:
- Biology and therapy of rhabdomyosarcoma and other childhood tumors
- Chemotherapy of childhood solid tumors
- Regulation of alternative pre-mRNA splicing
- Regulation and function of tumor suppressor genes
- Oncolytic viral therapy in pediatric brain tumors
- Immunotherapy and cellular therapies that harness the natural ability of the immune system to fight cancers
Meet Our Team
Learn more about director Stephen Lessnick, MD, PhD, and his team of principal investigators at the Center for Childhood Cancer and Blood Diseases.
Under the direction of Dawn Chandler, PhD, the Chandler Lab focuses on the regulation of pre-mRNA splicing and its disruption leading to pediatric cancer and spinal muscular atrophy.
Timothy Cripe Lab
Under the direction of Timothy Cripe, MD, PhD, the Cripe Lab focuses on developing and testing new, targeted therapies for pediatric solid tumors and translating those findings into clinical studies.
Affiliations and Collaborations
World-renowned Biopathology Center
The Biopathology Center at Nationwide Children’s Hospital serves as the only pediatric repository for pediatric solid tumor and is one of only two repositories for leukemia samples in the United States, Canada and Australia.