Center for Microbial Pathogenesis

The emphasis of the Center for Microbial Pathogenesis is to develop a greater understanding of the molecular mechanisms by which microorganisms cause infectious diseases, as well as how the host responds to these disease states.

Despite recent progress in the worldwide management of childhood infectious diseases, including the development and licensure of several new safe and effective pediatric vaccines, infectious disease remains the leading cause of death globally and is the third leading cause of mortality in The United States. There is thus a burgeoning need, on a national and international level, to develop methods to combat endemic diseases for which there are no effective treatments or vaccines. It is also imperative to take on the challenges presented by new and re-emerging infectious diseases caused by viruses, bacteria and eukaryotic pathogens.

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The Research Institute is ranked among the top 10 for NIH funding among free-standing children's hospitals.

Our Goals 

The goals of the Center for Microbial Pathogenesis are to identify virulence mechanisms and define host response patterns with the overall objective of elucidating a detailed description of the structure, function and control of biological systems in health and disease, utilizing molecular and cellular, as well as genomic and proteomic approaches. Knowledge generated from these studies and similar lines of investigation will enable CMP investigators to identify novel molecular targets that can be exploited for the conduct of translational research – the development of innovative approaches to the diagnosis, treatment and prevention of pediatric infectious and inflammatory diseases, as well as immunological disorders.

Areas of Focus

  • Multi-directional interactions between gut microbes, immune and nervous systems (Bailey Lab) 
  • Development of novel vaccine and therapeutic approaches that target the biofilms of chronic polymicrobial respiratory tract infections (otitis media, exacerbations of COPD) (Bakaletz Lab) 
  • Host-pathogen interactions as they relate to the pathogenic Neisseriaceae (Edwards Lab) 
  • Developing technologies to ‘build’ healthy biofilms (probiotics) and conversely, disrupt pathogenic biofilms (chronic infections) (Goodman Lab) 
  • Urinary tract infections: mechanisms, diagnosis, prevention and susceptibility factors (Justice Lab) 
  • Streptococcal interactions with host glycans and their effect on colonization and disease (King Lab) 
  • Study of the mechanisms by which macrophages fail to control infection and inflammation in patients with cystic fibrosis (CF) (Kopp Lab) 
  • Study of the stressor exposure effect on the microbiota, metabolites, and colonic inflammation (Maltz Lab) 
  • Nutritional and innate immune influences on bacterial pathogenesis (Mason Lab) 
  • Host-pathogen interactions in Staphylococcus aureus infection (Montgomery Lab) 
  • Mechanisms of recruitment and activation of phagocytic cell during infection or inflammation (Partida-Sanchez Lab)

Active Funding as Principal or Co-Principal Investigator

Faculty Member

Funding Institute

Role

Title

Dates

Total Project Costs

Bailey

NIH/NIMH

Co-PI

The role of the intestinal microbiome in anxiety and depression

9.1.17 – 8.31.20

$1,928,306

 

NIH/NIGMS

Co-PI

Tunable native probiotic formulations for the treatment of NEC

4.1.17 – 3.31.21

$1,574,367

Bakaletz

NIH/NIDCD

PI

Determinants of H. influenzae virulence in otitis media

9.30.99 – 7.31.20

$9,758,828

 

NIH/NIDCD

Co-PI

Otitis media: role of epigenetic regulation on NTHI pathogenesis and optimal vaccine design

8.1.16 – 7.31.21

$2,169,839

 

NIH/NIDCD

Co-PI

Novel immunotherapeutics for the management of otitis media due to H. influenzae

7.20.11 – 8.31.21

$5,391,631

Edwards

NIH/NIAID

Co-PI

Novel carbohydrate binding functions of the CR3 I-domain modulate gonococcal- cervical cell interactions

01.16.18 - 12.31.23

$2,299,137

Goodman

Scioto Biosciences

PI

Scioto Biosciences sponsored research

5.1.18 - 4.30.19

$250,000

 

NIH/NIGMS

Co-PI

A novel probiotic platform to treat necrotizing enterocolitis

8.1.17 - 4.30.19

$331,395

 

NIH/NIGMS

Co-PI

Tunable native probiotic formulations for the treatment of NEC

4.1.17 - 3.31.21

$1,882,628

 

NIH/NIDCD

Co-PI

Novel immunotherapeutics for the management of otitis media due to H. influenzae

7.20.11 - 8.31.21

$5,391,631

Gunn

NIH/NIAID

PI

Regulation of Francisella virulence by sRNAs

4.1.19 - 3.31.21

$418,000

 

NIH/NIAID

PI

Mechanisms of the development and maintenance of Salmonella gallbladder carriage

4.30.15 - 5.31.20

$3,243,500

Justice

NIH/NIDCD

Co-PI

Disease severity of otitis media: Biofilms, invasion, and host responses

12.1.13 – 11.30.19

$1,897,587

 

NIH/NIDDK

PI

Conference: Clinical and Scientific Advances in Urinary Tract Infections

3.1.19 – 2.29.20

$10,000

King

AHA

PI

The role of a serine rich repeat protein required for binding multiple carbohydrates in Streptococcus oralis endocarditis

7.1.17 – 6.30.19

$154,000

Kopp

Cystic Fibrosis Foundation

PI

CFTR modulator impact on macrophage function and inflammatory networks

11.01.16 – 4.30.19

$100,000

 

NIH/NIAID

PI

Burkholderia-mediated defective killing mechanisms in macrophages from CF patients

01.01.15 - 12.31.19

$756,000

 

Cystic Fibrosis Foundation

PI

Does CFTR control macrophage function?

11.1.18 – 10.31.19

$269,120

Mason

NIH/NIDCD

Co-PI

Disease severity of otitis media: Biofilms, invasion, and host responses

12.01.13 - 11.30.19

$1,897,587

 

NIH/NIAID

PI

A novel multifunctional role of diverse substrate binding and import by the Haemophilus Sap transporter

3.1.19 – 2.29.24

$2,380,531

Montgomery

NIH/NIAID

PI

Overcoming pathogen-mediated immune evasion: a translational approach to pediatric Staphylococcus aureus vaccine development

8.7.18-7.31.21

$1,520,000

Partida-Sanchez

Cystic Fibrosis Foundation

PI

CFTR controls calcium signaling and inflammatory functions of neutrophils

3.1.19 – 2.28.20

$125,000

Yu

NIH/NIAMS

PI

MHC Complement Variants in Disease Susceptibility of Idiopathic Inflammatory Myopathies

4.1.18 – 3.31.19

$171,692

 

NIH/NIAMS

PI

Complement in Human Lupus: Deficiencies, Profiles and Complications

7.8.18 – 5.31.19

$438,145