There are a variety of physical and behavioral disorders that have been linked to 22q11.2 deletion syndrome. The syndrome has the potential to impact every system in the body and can therefore lead to a wide-range of health issues. The majority of 22q11.2 deletion syndrome patients have congenital heart defects, most often conotruncal abnormalities (tetralogy of Fallot, interrupted aortic arch,
ventricular septal defect (VSD), vascular ring, and truncus arteriosus) and palatal defects, including submucosal cleft palate and
velopharyngeal dysfunction (VPD). VPD (also referred to as velopharyngeal insufficiency, or VPI) is usually manifest as abnormal nasal air escape and hypernasal speech. Some of the other common problems associated with 22q11.2 deletion syndrome include: