Institutional Review Board

The purpose of Nationwide Children's Institutional Review Board (IRB) is to review and provide oversight of all research involving human subjects at Nationwide Children’s Hospital and its affiliated institutions. This function is federally-mandated and regulated by the Department of Health and Human Services (45 CFR 46, including Subpart D which applies specifically to research in children) and the Food and Drug Administration (21 CFR 50 and 56). In addition the IRB is guided by the tenets of the Belmont Report, the International Committee on Harmonization's statement on Good Clinical Practices and the Declaration of Helsinki. The IRB has the authority to approve, require modifications in, or disapprove all research activities that fall within its jurisdiction as specified by both the federal regulations and local institutional policy.