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Nationwide Children’s Hospital Launches “Empower the Possible” Campaign with Historic 10-Year, $100 Million Commitment from Nationwide Foundation
Nationwide Children’s Hospital is honored to announce that it has received a historic 10-year commitment of $100 million from the Nationwide Foundation. This landmark announcement marks the public launch of the hospital’s “Empower the Possible” campaign that with other gifts brings the campaign’s fundraising total to more than $270 million, more than halfway to the campaign goal of $500 million.
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Featured Physician
Sean Tabaie, MD, MBA, FAAOS, FAOA, is a pediatric orthopedic surgeon at Nationwide Children’s Hospital and clinical professor at The Ohio State University College of Medicine. At Nationwide Children’s, Dr. Tabaie serves as the director of the Cerebral Palsy & Neuro-Orthopedics Program, medical director of the Honda Center for Gait Analysis and Mobility Enhancement, director of the Neuro-Orthopedics Fellowship, associate director of the Pediatric Orthopedics Fellowship and associate director of the Orthopedic Innovation Program.
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Human MicroRNA Inhibits Expression of Pathogenic Gene Underlying Facioscapulohumeral Muscular Dystrophy
Facioscapulohumeral muscular dystrophy (FSHD) is caused by aberrant expression of the DUX4 gene in skeletal muscles. Researchers at Nationwide Children’s Hospital have recently demonstrated that an endogenous human microRNA, miR-675, inhibits DUX4 expression and protects muscles from DUX4-mediated cell death in a mouse model when administered via gene therapy. They also showed that the small molecule-based treatments that upregulate miR-675 inhibited DUX4 mRNA and DUX4-associated biomarkers in myotubes derived from patients with FSHD.
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New Insights into the Role of the NOTCH1 Gene in Congenital Heart Defects
A new study published in Circulation Research provides novel insights into how mutations in the NOTCH1 gene may lead to abnormal differentiation and proliferation of cardiomyocytes and contribute to ventricular hypoplasia and other structural anomalies found in congenital heart defects in humans.
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FDA Grants Nationwide Children’s Hospital Researchers Safe-To-Proceed Authorization on First-In-World CAR-NK Cells Made with CRISPR/AAV
Researchers at Nationwide Children’s Hospital have received safe-to-proceed approval from the Food and Drug Administration (FDA) for Universal-Donor CD38KO CD33CAR-NK cells, to be studied in a forthcoming clinical trial. The Phase 1 trial will study the safety of the novel therapy in patients with advanced, high-risk acute myeloid leukemia (AML).
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Study Finds Teens Driving Older Vehicles Have Increased Risk for Fatal Crashes
Motor vehicle crashes are the leading cause of death for U.S. teens. Newer vehicles and driver assistance technologies show promise in reducing crashes and injury severities. Researchers at Nationwide Children’s Hospital reviewed national fatal crash data (2016-2021) and examined the vehicle age and driver assistance technologies of vehicles driven by teen and middle-aged drivers, and their associations with driver deaths during fatal crashes.
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Community Provider Corner
- Lectureship on Measles During ID Conference
- Franklin County Domestic Violence Hotline Transition
- Free Tax Help Available for Patient Families
- Continuing Education Credits
- Partners For Kids® Primary Care Webinar
- Patient Financial Assistance Program
- FDA Extends Approval for the Nexplanon® Birth Control Implant From 3 to 5 Years
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Primary Care Matters
Advancement With Intention: My Experience With an AI Scribe by Jonathan Mathis, MD, FAAP
News
Study Finds Adolescents with Concussion May Benefit from More Activity Earlier
Researchers at Nationwide Children’s Hospital have found that when it comes to concussion recovery, activity type matters. In a study published today in British Journal of Sports Medicine, researchers found that limiting screen time and returning to school early following a concussion may speed up recovery.
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New Study Highlights Urgent Need for Targeted Suicide Prevention and Mental Health Support for Sexual and Gender Diverse Youth
Researchers from the Center for Injury Research and Policy of the Abigail Wexner Research Institute at Nationwide Children’s Hospital analyzed six years of multistate child death review data from the United States and found that 81% of sexual and gender diverse youth in the dataset died by suicide, despite many receiving current or prior mental health services.