Nationwide Children's Research News
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Dec 13, 2021
Human MicroRNA Inhibits Expression of Pathogenic Gene Underlying Facioscapulohumeral Muscular Dystrophy
Facioscapulohumeral muscular dystrophy (FSHD) is caused by aberrant expression of the DUX4 gene in skeletal muscles. Researchers at Nationwide Children’s Hospital have recently demonstrated that an endogenous human microRNA, miR-675, inhibits DUX4 expression and protects muscles from DUX4-mediated cell death in a mouse model when administered via gene therapy. They also showed that the small molecule-based treatments that upregulate miR-675 inhibited DUX4 mRNA and DUX4-associated biomarkers in myotubes derived from patients with FSHD.
Sep 09, 2021
Alarming Upward Trend in Black Youth Suicide From 2003 to 2017
In the United States, the rates of suicide and suicidal behavior among youth, children and adolescents 5-17 years of age, have been steadily increasing over the last decade, and Black youth, 5-12 years, are approximately two times more likely to die by suicide than their White counterparts. However, the literature investigating Black youth suicide is extremely limited. For the first time, researchers have examined the trends and precipitating circumstances of suicide in Black youth only by age group and sex.
Aug 26, 2021
Every 46 Minutes a Child is Treated in a U.S. Emergency Department for an Injury from a Furniture or TV Tip-Over
Furniture and TV tip-overs are an important source of injury, especially for children younger than 6 years old. A recent study led by researchers at the Center for Injury Research and Policy at Nationwide Children’s Hospital found that an estimated 560,200 children younger than 18 years old were treated in U.S. emergency departments for furniture or TV tip-over injuries from 1990 through 2019. In 2019, there were 11,521 injured children, which is an average of one child every 46 minutes.
Aug 20, 2021
When Dismantling Bacterial Biofilms, the First Line of Defense Comes From Within
Researchers identified the mechanism behind the anti-biofilm properties of a protein found in all vertebrates. Too little of this protein allows disease-causing bacteria protected by biofilms to spread, while too much can lead to septic shock. Could a molecule of this protein be engineered to destroy biofilms without negative effects on the body?
Aug 06, 2021
An Alarming Connection Between Justice System Involvement and Child Health
A new study conducted at Nationwide Children’s Hospital’s Abigail Wexner Research Institute and published in the journal Health & Justice, appears to be the first to use electronic medical records and link children’s personal or family involvement in the correctional system to diagnoses – and the authors say the findings are so alarming they should be a call to action for pediatric providers.
Jul 29, 2021
New Study Finds Hands-free Cellphone Laws Associated with Fewer Driver Deaths
A recent study led by researchers at the Center for Injury Research and Policy at Nationwide Children’s Hospital looked at drivers, non-drivers (passengers, pedestrians, bicyclists, motorcyclists), and total deaths involved in passenger vehicle crashes from 1999 through 2016 in 50 U.S. states, along with the presence and characteristics of cellphone use laws.
Jul 27, 2021
Mental Health Concerns and Traumatic Events Are Common Among Young Children Who Die By Suicide
A study published today by Nationwide Children’s Hospital researchers found that although the circumstances around any suicide death are complex, there are often shared characteristics and experiences among young children who die by suicide.
Jun 28, 2021
Understanding Black Youth Suicide: Steps Toward Prevention
In a statement published in JAMA Pediatrics, researchers at the Nationwide Children’s Hospital, the University of North Carolina at Chapel Hill and the nonprofit research institute RTI International responded to a call from the National Institute of Mental Health (NIMH) requesting information on how to prevent Black youth suicide. The researchers emphasize the need for research and action of suicide prevention among Black youth must start from the ground up.
Jun 21, 2021
Virtual Reality as Pain Relief: Reducing Dressing Change Pain in Pediatric Burn Patients
Although opioids relieve burn injury-related pain, they have serious adverse side effects. Prior studies have investigated alternative approaches to pain reduction in burn injury patients that focus on distraction, such as music, hypnosis, toys, and virtual reality (VR). In a study published today in JAMA Network Open, Henry Xiang, MD, MPH, PhD, MBA, and his research team reported the use of smartphone-based VR games during dressing changes in pediatric patients with burn injuries.
Mar 15, 2021
Calls to Poison Centers about High-Powered Magnets Increased by 444% after Ban Lifted
A recent study led by researchers at the Center for Injury Research and Policy, Emergency Medicine, and the Central Ohio Poison Center at Nationwide Children’s Hospital along with the Children’s Hospital at Montefiore (CHAM) analyzed calls to U.S. poison centers for magnet exposures in children age 19 years and younger from 2008 through October 2019 to determine the impact of the CPSC rule and the subsequent lift of the ban.