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News
Human MicroRNA Inhibits Expression of Pathogenic Gene Underlying Facioscapulohumeral Muscular Dystrophy
Facioscapulohumeral muscular dystrophy (FSHD) is caused by aberrant expression of the DUX4 gene in skeletal muscles. Researchers at Nationwide Children’s Hospital have recently demonstrated that an endogenous human microRNA, miR-675, inhibits DUX4 expression and protects muscles from DUX4-mediated cell death in a mouse model when administered via gene therapy. They also showed that the small molecule-based treatments that upregulate miR-675 inhibited DUX4 mRNA and DUX4-associated biomarkers in myotubes derived from patients with FSHD.
News
Fostering Generosity in Children Makes the Holiday Season Bright for All
The holiday season often brings sharing, caring and providing joy for others. Whether families donate food, clothes or toys, spend time together volunteering in the community, or work to bring holiday cheer to pediatric patients in the hospital, generosity in all forms has an impact – including on one’s mental health.
Article
Henry Xiang Team
Henry Xiang, MD, MPH, PhD, MBA Principal Investigator Dr. Henry Xiang is a Professor of Medicine and Epidemiology at The Ohio State University. He is the founding Director of the Center for Pediatric Trauma Research as well as the Research Director at Center for Injury Research and Policy. Dr.
News
Columbus Area Child and Family Travel to Capitol Hill to Advocate for Neonatal Abstinence Syndrome Awareness
One local family is taking their story to Capitol Hill to deliver an important message to their members of Congress. Nationwide Children’s Hospital patient, Jack Baker, 2 and his family will join nearly 50 other pediatric patients and their families to meet with members of Congress and share
Article
Lab Staff
William Black, PhD, HSP Principal Investigator william.black@nationwidechildrens.org William Black, PhD, HSP, is a principal investigator in the Center for Biobehavioral Health at the Abigail Wexner Medical Research Institute at Nationwide Children's Hospital and an assistant professor of
News
Columbus Childrens Hospital Ranks 12th in U.S. News & World Reports 2007 Edition of Americas Best Childrens Hospitals
Columbus Childrens Hospital has ranked 12th on U.S. News & World Reports list of Americas Best Childrens Hospitals, moving up an impressive 10 places from 2006. For the first time, the pediatrics ranking is separate from the adult specialty listings and published in a separate issue of U.S.
News
Probiotics Delivered in Biofilm State Protect the Intestines and Brain in NEC Model
Researchers at Nationwide Children’s have been working on a novel solution to prevent NEC. They have developed a novel probiotic system that harnesses the durability of biofilms to improve the administration of probiotics to patients. It has been licensed to Scioto Biosciences. Their latest study, published in Nature Scientific Reports, describes the use of a biofilm formulation of Limosilactobacillus reuteri (Lr) to prevent NEC in a piglet model.
Specialty
Neuroimmunology Clinic
The Nationwide Children’s Hospital Neuroimmunology Clinic provides evidence-based, family-centered clinical care for infants, children and teens with autoimmune disorders that affect the central nervous system, known as neuroimmune disorders.
News
Nationwide Children’s Hospital’s “Light Up the Lawn, Light Up a Life” Makes Sparkling Return for Year Two
Nationwide Children’s Hospital’s “Light Up the Lawn, Light Up a Life” Campaign will return for its second year starting today, November 14. "Light Up the Lawn, Light Up a Life” is designed to brighten the holidays for children hospitalized at Nationwide Children’s, their families and the health care heroes caring for them.
Specialty
Vascular Anomalies Center
The Vascular Anomalies Center at Nationwide Children’s Hospital brings together a highly skilled interdisciplinary team of pediatric specialists to provide coordinated and comprehensive care for patients with vascular anomalies.