Charcot-Marie-Tooth (CMT) Center
The Charcot-Marie-Tooth (CMT) Center at Nationwide Children’s Hospital is nationally recognized for leading research and clinical care for patients with any of the hereditary motor and sensory neuropathy types. Backed by a multidisciplinary clinical team and ground-breaking research and clinical trials, the center provides the highest level of comprehensive care to patients from across the United States and internationally.
About the CMT Center
The Charcot-Marie-Tooth (CMT) Center at Nationwide Children’s Hospital provides comprehensive diagnostic evaluation and treatment for conditions within this group of inherited neurological disorders that affect an estimated 2.8 million adults and children worldwide.
Recognized as a Center of Excellence by the Charcot-Marie-Tooth Association (CMTA), the center comprises a unique multidisciplinary team comprising specialists in neuromuscular disorders, genetics counseling and orthopedics, as well as physical and occupational therapy. All clinical care is coordinated within one location, during a single clinic visit.
Learn about current research and clinical trials.
Zarife Sahenk, MD, PhD, a neurologist and researcher is director of the CMT Center. Dr. Sahenk serves as director of Clinical and Experimental Neuromuscular Pathology in the Abigail Wexner Research Institute and is a principle investigator in the Center for Gene Therapy. She is leading the upcoming Phase I/IIa Trial of scAAV1.tMCK.NTF3 for treatment of CMT1A.
Charcot-Marie-Tooth disease (CMT), also called hereditary motor and sensory neuropathy (HMSN), is a group of inherited neurological disorders affecting an estimated 2.8 million adults and children worldwide. Gene mutations reduce the ability of peripheral nerves to carry motor and sensory information, typically resulting in pain and slowly progressing weakness and muscle atrophy in the feet and lower legs then the hands and arms. In rare cases, CMT can affect breathing.
There is currently no cure for CMT, but symptoms of the disease can be managed through physical and occupational therapy, as well as use of orthopedic devices. In some cases, orthopedic surgery can help.
Investigators with the Center for Gene Therapy at Nationwide Children’s conduct numerous clinical research studies in neuromuscular disorders. To learn about enrolling in a current clinical trial, you may also call one of our study coordinators at (614) 722-2654.
- Neuromuscular Clinical Trials at Nationwide Children’s
- National Institutes of Health Clinical Trials
- NeuroNEXT: Network for Excellence in Neuroscience Clinical Trials
Nationwide Children’s Hospital provides services for families traveling from across the U.S.
- Global Patient Services (International)
- Patients Traveling from Outside of Columbus (Domestic)
- Ronald McDonald House
The following organizations provide numerous resources related to CMT.
The CMT Center accepts referrals from primary care physicians and pediatric specialists from the United States and internationally. To make a referral, there are three options:
- Request an appointment (select "Neuromuscular Disorders" under specialty)
- Fax a referral request to (614) 722-4000
- Make a referral and schedule by phone by calling (614) 722-6200 or toll-free (877) 722-6220
If you have questions about the CMT Center or an upcoming visit, call the Neuromuscular Disorders line at (614) 722-2203.