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Investigators Develop Technique to Effectively Edit NK Cells to Target Specific Cancer Cells
Originally, NK cells seemed promising for a natural therapy to fight cancer due to their innate ability to recognize any cells expressing stress or signs of infection. But investigators quickly realized they faced three key challenges: first, it was difficult to grow a large enough number of NK cells in the lab to offer useful infusions at a reasonable cost; second, an ideal universal donor solution was needed to make NK cell products faster, more reliably and with off-the-shelf availability; and third, NK cells were resistant to genetic modifications that might help them better target specific types of cancer cells. Nationwide Children’s Hospital investigators and their collaborators painstakingly solved the first two problems over the past decade. Now, they’ve conquered the third.
News
Justice Stores Third Annual National Fundraising Campaign to Benefit Nationwide Childrens Hospital Begins Feb. 26
For the third-consecutive year, tween retailer Justice (an Ascena Retail Group, Inc. company) will launch a national fundraising effort in their stores to benefit Nationwide Children’s Hospital. The “Give Hope” campaign will begin Feb.
News
Oligodendrocytes Induce Motor Neuron Death in ALS
A first-of-its-kind oligodendrocyte in vitro model shows that human cells normally supportive of motor neuron function play an active role in amyotrophic lateral sclerosis pathogenesis – and this discovery may point the way toward therapeutic timing and targets.
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Christina and Ryan Day Encourage Students to Take a “Day Time Break” for Mental Health as Part of On Our Sleeves Movement
Christina and Ryan Day are partnering with the On Our Sleeves™ movement to launch an interactive school-based program to help break stigmas, start important conversations and improve mental health awareness for students in more than 200 middle and high schools in Franklin and surrounding counties.
News
Jaimie D. Nathan, MD, Achieves Surgical Milestone: 100th TPIAT Procedure
Nationwide Children’s Hospital congratulates Jaimie D. Nathan, MD, on a significant milestone in an advanced procedure known as a total pancreatectomy with islet autotransplantation (TPIAT). Dr. Nathan performed his 100th TPIAT on September 19, 2023.
Blog
Scleroderma: What Parents Need to Know
Each person’s skin is unique, so scleroderma looks different for every patient. A child or young adult may start out with a small area of affected skin that changes in texture. Some people describe the skin as becoming tighter, firmer, more stretched, or thickened. The affected area may lighten, darken, or develop a red border.
News
Discovery of New Form of Dystrophin Protein Could Lead to Therapy for Some DMD Patients
Scientists have discovered a new form of dystrophin, a protein critical to normal muscle function, and identified the genetic mechanism responsible for its production. Studies of the new protein isoform, published online Aug.
News
Fairfield Medical Center Nursing Staff Receives Telemedicine Training
Without ever leaving Fairfield Medical Center, children and newborns will be able to receive clinical assessments from specialists an hour away at Nationwide Children’s Hospital.
News
New Blood-Based Genomic Marker for Tuberculosis May Help Identify Patients Who Will Develop the Disease
It may soon be possible to identify patients who will develop tuberculosis, as scientists have identified changes in the blood specific to the disease.
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SEARCH Summer Scholars
Learn more about the Nationwide Children's Hospital SEARCH Summer Scholars program.