Long-Sheng Chang, PhD

• Hematology/Oncology & BMT
  Principal Investigator
• Center for Childhood Cancer
  Principal Investigator
• Primary Department
  Center for Childhood Cancer

Dr. Chang is interested in genetic diseases that predispose individuals to the development of multiple nervous system tumors and other debilitating manifestations. Over the past two decades, he has been studying neurofibromatosis (NF), particularly neurofibromatosis type 2 (NF2), which is caused by mutations in the NF2 tumor suppressor gene. Using transgenic and gene knockout approaches, his lab has discovered specific regulation of NF2 gene expression and identified novel NF2 function during neural and mammary gland development and tumorigenesis. In addition, the lab has generated several cell culture and animal models for NF2-associated schwannomas and meningiomas. Using these models, his lab has evaluated novel targeted small-molecule drugs and natural compounds and identified AR-42, a histone deacetylase inhibitor, as a potential treatment for NF2-associated tumors. In addition, Dr. Chang is interested in studying the tumors associated with other NF, including NF1 and schwannomatosis. The ultimate goal of his research is to develop efficacious medical treatments for these NF-associated nervous system tumors, ultimately leading to substantial improvement of clinical care and long-term treatment outcomes for these patients. In addition, Dr. Chang’s laboratory is investigating molecular pathogenetics of hereditary Ménière’s disease and other hearing disorders.

Publications

2015 - Present Journal of Otolaryngology Head & Neck Surgery, Herald Scholarly Open Access, Editorial Board Member

2014 - Present Austin Otolaryngology, Austin Publications, LLC, Editorial Board Member

2013 - Present International Journal of Medicine, Science Publishing Corp., Editorial Board Member

2012 - Present Journal of Applied Medical Sciences, International Scientific Press, Editorial Board Member

2010 - Present International Journal of Clinical Medicine, Scientific Research Publishing, Inc., Editorial Board Member

2007 - Present Department of Pediatrics, The Ohio State University College of Medicine, and Center for Childhood Cancer, Children's Research Institute, Children's Hospital, Professor

2007 - Present Departments of Molecular Cellular Biochemistry, Pathology, Otolaryngology, and Vet. Biosci., The Ohio State University, Adjunct Professor

2007 - Present Departments of Molecular Cellular Biochemistry, Pathology, Otolaryngology, and Vet. Biosci., Adjunct Professor

2001 - Present Department of Otolaryngology, The Ohio State University College of Medicine, Otolaryngology Fellow Training Program Committee

2001 - Present The Annual Otolaryngology Alumni Symposium, Department of Otolaryngology, The Ohio State University College of Medicine, Judge, Otolaryngology Resident, and Fellow Presentations

1996 - Present Children's Hospital Research Foundation, Children's Hospital (Columbus, OH), Institutional Animal Care and Use Committee

1993 - Present Division of Hematology-Oncology, Department of Internal Medicine, The Ohio State University College of Medicine, Oncology Training Grant Committee

1990 - Present Molecular, Cellular, and Developmental Biology (MCDB) Program and Ohio State Biochemistry Program (OSBP), The Ohio State University, Member

2015 - 2015 Florida Department of Health’s Bankhead-Coley Cancer Research Program Proposal Review, Reviewer

2015 - 2015 Oak Ridge Institute for Science and Education (ORISE), Reviewer

2015 - 2015 Oak Ridge Associated Universities (ORAU), Reviewer

2015 - 2015 Committee of Initial Inquiry, Office of Research Compliance, The Ohio State University, Member

2013 - 2015 Internal Advisory Committee, Brain Tumors SPORE (Specialized Program of Research Excellence), Ohio Brain Tumor Working Group, Member

2013 - 2015 University Senate Committee on Academic Freedom and Responsibility, The Ohio State University, Chair

2012 - 2015 The University Senate’s Committee on Academic Freedom and Responsibility, The Ohio State University, Member

2014 - 2014 University Senate’s Ad Hoc Committee on New Media in the Classroom, The Ohio State University, Chair

2013 - 2013 The SEI Ad Hoc Committee, The Executive Committee of Faculty Council, The Ohio State University, Member

2012 - 2013 Pennsylvania Department of Health Final Performance Review - 12-13 Cycle B, Oak Ridge Associated Universities, Reviewer

2012 - 2013 Welcome Trust, Peer-Review Grant Reviewer

2012 - 2012 Peer-Review Grant Reviewer, The Brain Tumor Charity

2006 - 2012 University Senate's Committee on Academic Misconduct, The Ohio State University, Member

2006 - 2012 University Senate's Committee on Academic Misconduct, The Ohio State University, Member

2009 - 2009 Samantha Dickson Brain Tumour Trust, Peer-Review Grant Reviewer

2009 - 2009 The Department of Defense Neurofibromatosis Research Program, NF-B Review Panel, Peer-Review Scientific Reviewer

2008 - 2009 The Department of Defense Neurofibromatosis Research Program, Adhoc-1 Review Panel, Reviewer

2008 - 2008 Grants Committee, Medical Research Council, Referee

2007 - 2007 The Department of Defense Post-Traumatic Stress Disorder/Traumatic Brain Injury (PTSD/TBI) Research Program Panel 2, Peer-Review Online Reviewer

2007 - 2007 The Department of Defense Post-Traumatic Stress Disorder/Traumatic Brain Injury (PTSD/TBI) Research Program Panel 4, Peer-Review Scientific Reviewer

2003 - 2007 Department of Veterinary Biosciences, The Ohio State University, Adjunct Associate Professor

2001 - 2007 Department of Otolaryngology, The Ohio State University College of Medicine, Adjunct Associate Professor

1998 - 2007 Department of Pathology, The Ohio State University College of Medicine, Adjunct Associate Professor

1996 - 2007 Department of Molecular Cellular Biochemistry (former Medical Biochemistry), The Ohio State University College of Medicine, Adjunct Associate Professor

1996 - 2007 Department of Pediatrics, Children's Hospital and The Ohio State University, Associate Professor

2006 - 2006 Grants Committee, Medical Research Council, UK, Referee

1993 - 2006 Molecular Cellular Development Biology Program, The Ohio State University, Graduate Studies Committee

2005 - 2005 Cancer Research Program, The US Army Medical Research and Material Command (USAMRMC) Congressionally Directed Medical Research Program (CDMRP), Peer-Review Panel Member

2005 - 2005 Cancer Research Program, The US Army Medical Research and Material Command (USAMRMC) Congressionally Directed Medical Research Program (CDMRP), Peer-Review Panel Member

2005 - 2005 Project Grants Committee, Cancer Research UK, Referee

2002 - 2003 The Center for Childhood Cancer Bi-monthly Research Meeting, Children's Research Institute (Columbus, OH), Organizer

1998 - 2003 Ohio State Biochemistry Program, The Ohio State University, Graduate Admission Committee

1999 - 1999 11th Annual Stone Lab Meeting, The Ohio State University Comprehensive Cancer Center Molecular Biology Human Cancer Genetics Program, F.T. Stone Laboratory, The Ohio State University, Organizer

1998 - 1998 10th Annual Stone Lab Meeting, The Ohio State University Comprehensive Cancer Center Molecular Biology & Human Cancer Genetics Program, F.T. Stone Laboratory, The Ohio State University, Co-organizer

1997 - 1998 Molecular, Cellular, & Developmental Biology Program, The Ohio State University, Rotation Research Advisory Committee

1995 - 1996 Children's Hospital (Columbus, OH), Design Task Force for Wexner Institute for Pediatric Research

1995 - 1996 The Ohio State University Comprehensive Cancer Center Transgenic Mouse Facility at Children's Hospital, The Ohio State University, Laboratory Director

1993 - 1996 Biotechnology Center, The Ohio State University, Transgenic Advisory Committee

1991 - 1996 Children's Hospital Research Foundation, Children's Hospital (Columbus, OH), Program Committee

1991 - 1996 Department of Medical Biochemistry, The Ohio State University College of Medicine, Adjunct Assistant Professor

1990 - 1996 Department of Pediatrics, Children's Hospital and The Ohio State University College of Medicine (Columbus, OH), Assistant Professor

1994 - 1995 Children's Hospital Research Foundation, Children's Hospital (Columbus, OH), Product Standardization Committee

1994 - 1995 College of Medicine, The Ohio State University, Gene Therapy Task Force

1992 - 1995 Children's Hospital Research Foundation, Children's Hospital (Columbus, OH), Strategic Planning Task Force Committee

1992 - 1995 Children's Hospital Research Foundation, Children's Hospital (Columbus, OH), Operation Committee

1991 - 1995 The Ohio State University/Children's Hospital Transgenic Mouse Facility (Columbus, OH), Laboratory Director

1988 - 1990 Department of Molecular Biology, Princeton University, Research Staff Member

1985 - 1987 Leukemia Society of America, Leukemia Society Research Fellow

1985 - 1985 Department of Molecular Biology, Princeton University, Research Associate

Center for Childhood Cancer